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Art. -Nr.: HY-184440

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Complex I-IN-1

Complex I-IN-1 is a novel fungicide that acts as a mitochondrial complex I inhibitor. Complex I-IN-1 regulates oxidoreductase activity, glycolysis/gluconeogenesis, methionine metabolism, and the MAPK signaling pathway in Blumeria graminis. Complex I-IN-1 is applicable to research related to wheat powdery mildew.

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CAS. Nr.: 3080323-62-9
Formel: C₁₆H₁₂Cl₅F₂N₃O₂
Molecular Weight:493.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Complex I-IN-1 Chemical Structure

CAS. Nr.: 3080323-62-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

In Vitro

Fungal InfectionMitochondrial FunctionCarbohydrate MetabolismProtein/Amino Acid MetabolismMitochondrial Oxidative PhosphorylationApoptosis

Fungal Infection

Complex I-IN-1 exhibits excellent activity against wheat powdery mildew (EC₅₀ = 0.440 mg/L)^[1].

Mitochondrial Function

Carbohydrate Metabolism

Protein/Amino Acid Metabolism

Mitochondrial Oxidative Phosphorylation

Fungal Infection

Apoptosis

Complex I-IN-1 alters gene expression in mycelia of Blumeria graminis, and the differentially expressed genes (DEGs) are enriched in pathways associated with mitochondrial complex I function, confirming complex I as its potential target^[1].

Mitochondrial Function

Mitochondrial Oxidative Phosphorylation

Complex I-IN-1 (compound 3) binds to the active site of yeast mitochondrial Complex I and interacts with surrounding key amino acid residues, which is consistent with its function as a Complex I inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3080323-62-9
Molecular Weight 493.55
Formel C₁₆H₁₂Cl₅F₂N₃O₂
SMILES

Cl/C(Cl)=C/COC1=CC(Cl)=C(OCCNC2=C(Cl)C(C(F)F)=NC=N2)C(Cl)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jia WF, et al. Design, Synthesis, and Fungicidal Activity of Pyrimidinamine Derivatives as Novel Complex I Inhibitors. Journal of agricultural and food chemistry. 2026 Jun 24;74(24):18551-18563. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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