ERK-IN-6
ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma (ESCC). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C19H18BrN3O3S
- Molecular Weight:448.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 16.8 µM (KYSE-30), 10.07 µM (KYSE-150), 13 µM (HET-1A), 202.2 µM (NES-G4T)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HET-1A | IC50 |
13 μM
Compound: 6g
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Antiproliferative activity against human HET-1A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HET-1A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 36508971] |
| KYSE-150 cell line | IC50 |
10.07 μM
Compound: 6g
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Antiproliferative activity against human KYSE-150 cell line assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KYSE-150 cell line assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 36508971] |
| KYSE-30 | IC50 |
16.8 μM
Compound: 6g
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Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 36508971] |
In Vitro
ERK-IN-6 (0-10 µM; 72 h) inhibits cell proliferation of ESCC cells[1]. ERK-IN-6 (10 µM; 48-72 h) induces cell apoptosis through the ERK pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KYSE-30, KYSE-150, HET-1A and NES-G4T cell lines
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Concentration:0-10 µM
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Incubation Time:72 hours
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Result:Dose-dependently inhibited cell proliferation of KYSE-30, KYSE-150, HET-1A and NES-G4T cells with IC50 values of 16.8, 10.07, 13 and 202.2 µM, respectively.
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Cell Line:KYSE-30 and KYSE-150 cell lines
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Concentration:10 µM
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Incubation Time:48 and 72 hours
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Result:Induced KYSE-30 and KYSE-150 cell apoptosis with the loss of nuclei integrity at 72 h.
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Cell Line:KYSE-150 and NES-G4T cell lines
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Concentration:10 µM
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Incubation Time:4, 8 and 12 hours
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Result:Time-dependently down regulated pERK.
Chemical Information
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Molecular Weight 448.33
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Formel C19H18BrN3O3S
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SMILES
CC1(C)N/C(S/C1=C\C2=CC=C(Br)C=C2)=N/C3=CC=C(OC)C=C3[N+]([O-])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ERK-IN-6 Related Classifications
HY-151934 Related Classifications
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