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Art. -Nr.: HY-189667

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Ferroptosis inducer-18

Ferroptosis inducer-18 is a ferroptosis inducer targeting NQO1. Ferroptosis inducer-18 acts as an NQO1 substrate, undergoes redox cycling, and produces partial cytotoxicity. Ferroptosis inducer-18 induces ROS generation, triggering lipid peroxidation and DNA damage. Ferroptosis inducer-18 exhibits selective cytotoxicity against prostate cancer cells, causing increased cytoplasmic volume, vacuolization, and loss of membrane integrity in prostate cancer cells. Ferroptosis inducer-18 can be used in prostate cancer-related research.

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CAS. Nr.: 2925251-41-6
Formel: C₃₄H₂₆N₄O₆
Molecular Weight:586.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ferroptosis inducer-18 Chemical Structure

CAS. Nr.: 2925251-41-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

NQO1

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC50	0.97 μM	Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 24 hrs by MTT assay. Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 24 hrs by MTT assay.	acsomega.5c11250
DU-145	IC50	1.04 μM	Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 48 hrs by MTT assay. Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 48 hrs by MTT assay.	acsomega.5c11250
DU-145	IC50	0.96 μM	Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 72 hrs by MTT assay. Cytotoxicity against human DU-145 prostate cancer cells assessed as viability reduction after 72 hrs by MTT assay.	acsomega.5c11250
MRC5	IC50	3.90 μM	Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 24 hrs by MTT assay. Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 24 hrs by MTT assay.	acsomega.5c11250
MRC5	IC50	3.79 μM	Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 48 hrs by MTT assay. Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 48 hrs by MTT assay.	acsomega.5c11250
MRC5	IC50	3.60 μM	Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 72 hrs by MTT assay. Cytotoxicity against human MRC-5 nontumor fibroblasts assessed as viability reduction after 72 hrs by MTT assay.	acsomega.5c11250

In Vitro

Ferroptosis inducer-18 (compound 4) acts as an NQO1 substrate with a relative enzymatic activity of 76.96% and forms an NQO1 complex with a melting temperature of 51.78 °C^[1].
Ferroptosis inducer-18 (0.098-12.5 μM; 24-72 h) exhibits potent and time-independent cytotoxicity in DU-145 prostate cancer cells and is selective against MRC-5 fibroblasts^[1].
Ferroptosis inducer-18 (0.5-1 μM; 24 h) reduced DU-145 cell density and membrane integrity in a concentration-dependent manner, with viability decreasing to 48.83% at 1 μM^[1].
Ferroptosis inducer-18 exhibits low hemolytic activity in mouse erythrocytes, with EC₅₀ > 200 μM and a hemolysis rate of 1.04%^[1].
Ferroptosis inducer-18 (24 h) cytotoxicity in DU-145 cells can be reduced by pre-incubation with NAC (HY-B0215) (5 mM), increasing the IC₅₀ from 0.97 μM to 3.28 μM^[1].
Ferroptosis inducer-18 (1 μM; 6 h) induced lipid peroxidation in DU-145 cells with an oxidation rate of 1.51^[1].
Ferroptosis inducer-18 (0.04-12.5 μM; 24 h) exhibits cytotoxicity in DU-145 cells that is partially dependent on NQO1, with the IC₅₀ increasing from 0.97 μM to 2.02 μM in the presence of Dicoumarol (HY-N0645), while remaining potent in NQO1-low-expressing HL-60 cells^[1].
Ferroptosis inducer-18 (0.97 μM; 24 h) combined with deferoxamine rescue increased DU-145 cell viability, indicating the presence of iron-dependent ferroptosis^[1].
Ferroptosis inducer-18 (3-24 h) induces ROS in DU-145 cells^[1].
Ferroptosis inducer-18 (0.5-1 μM; 24 h) induces oxidative DNA damage in DU-145 cells, which is reduced by NAC and enhanced by hOGG1^[1].
Ferroptosis inducer-18 (0.5-1 μM; 6-24 h) induces mitochondrial depolarization in DU-145 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

DU-145 prostate cancer cells
Concentration:

0.5, 1 μM
Incubation Time:

24 h
Result:

Caused increased cytoplasmic size.
Flow cytometry showed cellular densities of 13.71 × 10^4 cells/mL at 0.5 μM and 8.23 × 10^4 cells/mL at 1 μM.
Membrane integrity/viability was 83.37% at 0.5 μM and 48.83% at 1 μM.

Cell Viability Assay^[1]

Cell Line:

DU-145 prostate cancer cells
Concentration:

0.97 μM
50, 100 μM (DFO (HY-D0903))
Incubation Time:

24 h
Result:

Gave 14.18% cell viability alone.
With DFO 50 μM, viability increased to 48.73%; with DFO 100 μM, viability increased to 62.54%.
DFO increased viability more than 3-fold compared with compound 4 alone.

Related Protocols :

Chemical Information

CAS. Nr. 2925251-41-6
Molecular Weight 586.59
Formel C₃₄H₂₆N₄O₆
SMILES

CC1(OC2=C(C1N3C=C(N=N3)CNC4=CC(C5=C(C(OCC6=CC=CC=C6)=CC=C5)C4=O)=O)C(C(C7=CC=CC=C72)=O)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Eleicy N. Mendoza, et al. Prodrug-like Quinone Containing Two Redox-Active Centers Induces Ferroptosis in Prostate Cancer Cells with Cytotoxic Action Partially Depending on NAD(P)H Quinone Dehydrogenase 1 (NQO1). ACS Omega. 2026 Aug 25;11(35):52411–52426.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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Ferroptosis inducer-18