Fumonisin B3
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Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.
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- Reinheit: 99.51%
- CAS. Nr.: 1422359-85-0
- Formel: C34H59NO14
- Molecular Weight:705.83
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Biologische Aktivität
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Fungal Metabolite |
Fumonisin B3 (2-16 µg per egg; air sac injection; single dose) induces dose-dependent mortality in broiler chicken embryos, with a mortality rate of 14.6% at 16 µg per egg and 8.0% at 2 µg per egg; it also causes hemorrhage in dead embryos but exerts no teratogenic effect on surviving embryos[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:strain not specified[1]
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Dosage:0.05%; 0.1%
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Administration:diet; daily; 15 to 20 days
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Result:Induced gamma glutamyltranspeptidase positive (GGT+) foci in rat livers following 15 to 20 day dietary exposure.
Led to formation of hepatocyte nodules after subsequent AAF/PH treatment.
Closely mimicked the short-term toxic and cancer initiating effects of Fumonisin B1.
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Animal Model:Peterson-Arbor Acres broiler embryos (72 h incubated prior to toxin injection)[2]
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Dosage:2 µg per egg; 16 µg per egg
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Administration:air cell injection; single dose
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Result:Resulted in 8.0% cumulative embryonic mortality at 18 days of incubation, with no significant differences in hatchability and hatching weight compared to controls.
Resulted in 14.6% cumulative embryonic mortality at 18 days of incubation, which was significantly higher than control groups but not significantly different from the FB2 treatment group.
Caused all mortality within 7 days post-injection, with dead embryos showing severe hemorrhages in the back of the head, neck, and thoracic area.
Showed no gross developmental abnormalities and no significant difference in embryonic body weight compared to controls for surviving 18-day embryos.
Chemical Information
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CAS. Nr. 1422359-85-0
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Appearance Liquid (Density: 1.222 g/cm3)
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Molecular Weight 705.83
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Formel C34H59NO14
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Color Colorless to light yellow
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SMILES
C[C@@H]([C@H](CCCCCC[C@H](C[C@@H](C[C@@H]([C@@H]([C@@H](CCCC)C)OC(C[C@@H](CC(O)=O)C(O)=O)=O)OC(C[C@@H](CC(O)=O)C(O)=O)=O)C)O)O)N
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Structure Classification
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Initial Source
Fusarium moniliforme
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Gelderblom WC, et al. Fumonisins: isolation, chemical characterization and biological effects. Mycopathologia. 1992;117(1-2):11-16. [Content Brief]
[2]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Fumonisin B3 Related Classifications
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