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Art. -Nr.: HY-163405

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Galectin-3-IN-3

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively.

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CAS. Nr.: 2491661-50-6
Formel: C₂₅H₂₂ClF₂N₇O₄S
Molecular Weight:590.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Galectin-3-IN-3 Chemical Structure

CAS. Nr.: 2491661-50-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC₅₀ values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively^[1].

IC₅₀ & Target

hGal-3

11 nM (IC₅₀)

mGal-3

84 nM (IC₅₀)

hGal-1

2720 nM (IC₅₀)

hGal-9

3530 nM (IC₅₀)

Alle Galectin Isoform-spezifische Produkte anzeigen :

In Vivo

Galectin-3-IN-3 (2 mg/kg; i.v.; single dose) exhibits low clearance rate (CL=8 mL/min/kg), high volume of distribution (V_ss=1.8 L/kg), and good oral bioavailability (F=40%) in mice plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2491661-50-6
Molecular Weight 590.00
Formel C₂₅H₂₂ClF₂N₇O₄S
SMILES

CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Galectin-3-IN-3

Alle Galectin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Galectin-3-IN-3 Related Classifications

HY-163405 Related Classifications