OSBPL11 - oxysterol binding protein like 11 Gene

Also Known as ORP11; ORP-11; OSBP12; TCCCIA00292

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114885

About OSBPL11

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:125,528,858-125,595,497 (from NCBI)

This gene has 1 transcript (splice variant), 211 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

OSBPL11 Products (1)

mRNA Protein Name
NM_022776.5 NP_073613.2 oxysterol-binding protein-related protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
23028956 GOA
involved in positive regulation of sequestering of triglyceride IMP
IMP: Inferred from mutant phenotype
23028956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL11 Protein Structure

PH

PH: PH domain (63 - 154)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (371 - 727)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 11

  • OSBP-related protein 11

OSBPL11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
OSBPL11 Q9BXB4 OSBPL9 Homo sapiens Q96SU4
Anti Tag CoIP
35271311
Intra
OSBPL11 Q9BXB4 OSBPL9 Homo sapiens Q96SU4
BiFC
22906437
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Splenic Manifestation Of Leukemia

  • Splenic Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09838 OSBPL11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OSBPL11 VGNC VGNC:75631
Bos taurus OSBPL11 VGNC VGNC:32459
Mus musculus OSBPL11 MGD MGI:2146553
Canis familiaris OSBPL11 VGNC VGNC:44152
Felis catus OSBPL11 VGNC VGNC:63977
Rattus norvegicus OSBPL11 RGD RGD:1307294
Others OSBPL11 NCBI