ADORA2B - adenosine A2b receptor Gene

Also Known as ADORA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 136

About ADORA2B

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,850,362-15,975,746 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues.

Summary

This gene encodes an Adenosine Receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates Adenylate Cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

ADORA2B Products (7)

mRNA Protein Name
XM_011523661.3 XP_011521963.1 adenosine receptor A2b isoform X4
XM_047435374.1 XP_047291330.1 adenosine receptor A2b isoform X2
XM_047435373.1 XP_047291329.1 adenosine receptor A2b isoform X2
XM_011523659.4 XP_011521961.1 adenosine receptor A2b isoform X2
XM_017024197.3 XP_016879686.1 adenosine receptor A2b isoform X1
NM_000676.4 NP_000667.1 adenosine receptor A2b
XM_047435375.1 XP_047291331.1 adenosine receptor A2b isoform X3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
29568380 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADORA2B Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (24 - 290)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

adenosine receptor A2b

ADORA2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ADORA2B P29275 ADORA2A Homo sapiens P29274
BRET
29568380
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Inner Ear Disease

  • Labyrinthine Dysfunction

  • Diseases Of Inner Ear

  • Labyrinthine Disease

  • Abnormality Of The Inner Ear

  • Labyrinth Diseases

  • Labyrinthine Disorder

  • Nonfunctioning Labyrinth

  • Labyrinthine Loss Of Function

  • Labyrinthine Syndrome

  • Labyrinthine Disorder Nos
Priapism

  • Mentulagra

  • Priapism, Familial Idiopathic

  • Familial Idiopathic Priapism

  • Pathologic Erection

  • Painful Erection
Subacute Leukemia
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Myocardial Stunning
Barre-Lieou Syndrome

  • Cervicocranial Syndrome

  • Posterior Cervical Sympathetic Syndrome
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Adenosine Deaminase Deficiency

  • Ada Deficiency

  • Ada-Scid

  • Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

  • Adenosine Deaminase Deficient Severe Combined Immunodeficiency

  • Scid Due To Ada Deficiency

  • Severe Combined Immunodeficiency Due To Ada Deficiency

  • Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency

  • Ada

  • Scid Due To Adenosine Deaminase Deficiency
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADORA2B VGNC VGNC:25688
Mus musculus ADORA2B MGD MGI:99403
Canis familiaris ADORA2B VGNC VGNC:37667
Rattus norvegicus ADORA2B RGD RGD:2050
Others ADORA2B NCBI