HLA-G - major histocompatibility complex, class I, G Gene

Also Known as MHC-G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3135

About HLA-G

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:29,826,474-29,831,021 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 560 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 29.5), colon (RPKM 14.0) and 15 other tissues.

Summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-G Products (8)

mRNA	Protein	Name
NM_001363567.2	NP_001350496.1	HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor
NM_001384280.1	NP_001371209.1	HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor
NM_001384290.1	NP_001371219.1	HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor
NM_002127.6	NP_002118.1	HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor
NM_001363567.2	NP_001350496.1	HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor
NM_001384280.1	NP_001371209.1	HLA class I histocompatibility antigen, alpha chain G isoform 1 precursor
NM_001384290.1	NP_001371219.1	HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor
NM_002127.6	NP_002118.1	HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables CD8 receptor binding	IDA IDA: Inferred from direct assay	12853576	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16455647	GOA
enables peptide antigen binding	IDA IDA: Inferred from direct assay	7584149	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9640257	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12874224	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20702625	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA IDA: Inferred from direct assay	7584149	GOA
involved in immune response-inhibiting cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	20702625	GOA
involved in negative regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	24453251	GOA
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	11290782	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	20702625	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	16809620	GOA
involved in negative regulation of dendritic cell differentiation	IDA IDA: Inferred from direct assay	20702625	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	10190900	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	12874224	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	24453251	GOA
involved in peripheral B cell tolerance induction	IDA IDA: Inferred from direct assay	24453251	GOA
involved in positive regulation of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	20448110	GOA
involved in positive regulation of cellular senescence	IDA IDA: Inferred from direct assay	23184984	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	16809620	GOA
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	20702625	GOA
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	19304799	GOA
involved in positive regulation of natural killer cell cytokine production	IDA IDA: Inferred from direct assay	16366734	GOA
involved in positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	20448110	GOA
involved in positive regulation of tolerance induction	IMP IMP: Inferred from mutant phenotype	22802125	GOA
involved in protection from natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	11290782	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	12874224	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cis-Golgi network membrane	IDA IDA: Inferred from direct assay	12582157	GOA
located in early endosome	IDA IDA: Inferred from direct assay	16366734	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7584149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-G Protein Structure

MHC_I

C1-set

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
HLA class I histocompatibility antigen, alpha chain G	HLA G antigen

HLA-G Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HLA-G	P17693	LILRB2	Homo sapiens	Q8N423	SPR	24018270
Intra	HLA-G	P17693	LILRB2	Homo sapiens	Q8N423	Comig Non-Denat Gel	16455647
Intra	HLA-G	P17693	LILRB2	Homo sapiens	Q8N423	SPR	12853576
Intra	HLA-G	P17693	HLA-G	Homo sapiens	P17693	Comig Non-Denat Gel	16455647
Intra	HLA-G	P17693	HLA-G	Homo sapiens	P17693	GMS	16455647
Intra	HLA-G	P17693	LILRB1	Homo sapiens	Q8NHL6	Affinity Techniques	19583775
Intra	HLA-G	P17693	HLA-G	Homo sapiens	P17693	Comig Non-Denat Gel	18550825
Intra	HLA-G	P17693	LILRB1	Homo sapiens	Q8NHL6	GMS	16455647
Intra	HLA-G	P17693	HLA-G	Homo sapiens	P17693	GMS	18550825
Intra	HLA-G	P17693	LILRB2	Homo sapiens	Q8N423	GMS	16455647
Intra	HLA-G	P17693	LILRB1	Homo sapiens	Q8NHL6	SPR	24018270
Intra	HLA-G	P17693	HLA-G	Homo sapiens	P17693	Comigration in SDS	16455647
Intra	HLA-G	P17693	LILRB1	Homo sapiens	Q8NHL6	Comig Non-Denat Gel	16455647
Intra	HLA-G	P17693	LILRB1	Homo sapiens	Q8NHL6	SPR	12853576

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HLA-G Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71667	HLA-G Protein, Human (HEK293, His)	P17693-1 (G25-D338)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72227	HLA-G Protein, Human (His-SUMO)	P17693-1 (G25-D338)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77688	HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein, Human (HEK293, His-Avi)	P17693 (G25-T305)&P61769 (I21-M119)&RIIPRHLQL	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77689	HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)	P17693 (G25-T305)&P61769 (I21-M119)&RIIPRHLQL	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77690	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Human (HEK293, His-Avi)	P17693-1 (G25-T305)&P61769 (I21-M119)&RIIPRHLQL	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77691	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Human (Biotinylated, HEK293, His-Avi)	P17693 (G25-T305)&P61769 (I21-M119)&RIIPRHLQL	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78455	HLA-G Protein, Human (C66S, His-Avi)	P17693-1 (G25-T305, C66S)	≥ 95%, as determined by Bis-Tris PAGE.

HLA-G Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83480	HLA G Antibody (YA3225)	WB	Human

Related Diseases

Diseases	Alias
Severe Pre-Eclampsia	Severe Preeclampsia Antepartum Severe Pre-Eclampsia Postpartum Severe Pre-Eclampsia Severe Pre-Eclampsia, With Delivery Severe Toxemia Severe Pre-Eclampsia, Antepartum Condition Or Complication Severe Pre-Eclampsia, Postpartum Condition Or Complication Severe Puerperal Pre-Eclampsia Severe Pre-Eclamptic Toxaemia Severe Pet - [Pre-Eclamptic Toxaemia]
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Choriocarcinoma	Chorioepithelioma
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Intrahepatic Cholestasis	Cholestasis, Intrahepatic Neonatal Intrahepatic Cholestasis Cholestasis Intrahepatic Cholestasis Of Pregnancy
Rabies	Lyssa Hydrophobia St Hubert Disease
Trypanosomiasis
Pregnancy Loss, Recurrent 1	Pregnancy Loss, Recurrent, Susceptibility To, 1 Rpl RPRGL1 Rprgl Recurrent Miscarriage Recurrent Spontaneous Abortion Abortion, Spontaneous, Recurrent Fetal Loss, Recurrent Fetal Loss, Recurrent, Susceptibility To Miscarriage, Recurrent Embryonic Loss, Recurrent Stillbirth, Recurrent Pregnancy Loss, Recurrent, 1 Recurrent Embryonic Loss Recurrent Fetal Loss Recurrent Stillbirth Spontaneous Recurrent Abortion Miscarriage Recurrent Pregnancy Loss, Recurrent, Susceptibility To, Type 1 Abortion, Habitual
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Ectopic Pregnancy	Eccyesis Pregnancy Ectopic Pregnancy, Ectopic Ectopic Pregnancies Extrauterine Gestation Or Pregnancy Extrauterine Pregnancy Ep - [Ectopic Pregnancy] Ectopic Mole Aborted Ectopic Pregnancy Ruptured Ectopic Pregnancy
Pemphigus Vulgaris, Familial	Pemphigus Vulgaris Familial Pemphigus Vulgaris Pemphigus
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Placental Site Trophoblastic Tumor	Trophoblastic Tumor Placental Site Trophoblastic Tumor, Placental Site Placental Site Trophoblastic Tumour Placental-Site Gestational Trophoblastic Neoplasm Placenta Neoplasm Psst Deciduoma Placental Cancer Primary Malignant Neoplasm Of Placenta
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Larynx Squamous Papilloma	Laryngeal Squamous Cell Papilloma
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Orbit Rhabdomyosarcoma	Rhabdomyosarcoma Of The Orbit Rhabdomyosarcoma Of Orbit
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Placenta Disease	Placenta Diseases Placenta Disorder Pregnancy Complications Placenta Disorders
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Persistent Fetal Circulation Syndrome	Persistent Fetal Circulation Fetal Circulation Persistent Pulmonary Hypertension Of The Newborn Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins Persistent Foetal Circulation Persistent Foetal Circulation Syndrome Pfc - [Persistent Fetal Circulation] Syndrome Pphn - [Persistent Pulmonary Hypertension Of The Newborn] Newborn Pulmonary Hypertension Primary Pulmonary Hypertension Of Newborn
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990061	Polzastobart	Inhibitor	97.81%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06217	HLA-G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169404	PPARγ agonist 15	Agonist	/	Unkown
HY-P11340	VMAPRTLFL	Ligand	/	Unkown

Inhibitory Antibodies (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990714	Obertamig	Inhibitor	95.803%	Unkown
HY-P992111	Elfritatug	Inhibitor	98.98%	Unkown
HY-P992018	Anti-HLA-G Antibody	Inhibitor	/	Unkown
HY-P992254	Anti-LAG-3 Antibody (BAP050)	Inhibitor	/	Unkown
HY-P992353	ES009	Antagonist	/	Unkown
HY-P992388	IO-108	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HLA-G	RGD	RGD:3494