ACRV1 - acrosomal vesicle protein 1 Gene

Also Known as SP-10; SPACA2; D11S4365

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56

About ACRV1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,671,522-125,680,847 (from NCBI)

This gene has 4 transcripts (splice variants), 91 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 39.8).

Summary

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

ACRV1 Products (4)

mRNA	Protein	Name
NM_001612.6	NP_001603.1	acrosomal protein SP-10 isoform a precursor
NM_020069.5	NP_064454.1	acrosomal protein SP-10 isoform b precursor
NM_020107.5	NP_064492.1	acrosomal protein SP-10 isoform c precursor
NM_020108.5	NP_064493.1	acrosomal protein SP-10 isoform d precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
acrosomal protein SP-10	sperm protein 10

ACRV1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Y2H Pooling	32814053
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32814053
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Validated Y2H	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Y2H Array	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Y2H Pooling	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACRV1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71139	SP-10/ACRV1 Protein, Human (HEK293, C-His)	P26436-1 (Q22-I265)	≥ 95%, as determined by reducing SDS-PAGE.

ACRV1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82111	ACRV1 Antibody (YA1856)	WB	Human
HY-P84219	ACRV1 Antibody (YA3916)	IHC-P, FC, ELISA	Human
HY-P84219A	ACRV1 Antibody (YA3916)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Byssinosis	Flax-Dressers' Disease Cotton Mill Fever Stripper'S Asthma Monday Morning Fever Cotton Workers' Lung Disease Cotton-Dust Asthma Mill Fever Lung Fibrosis With Byssinosis Airway Disease Due To Cotton Dust Respiratory Tract Disorder Due To Cotton Dust Strippers' Disease Flax-Dressers' Disorder Strippers' Asthma
Hordeolum	Stye Boil Of Eyelid Furuncle Of Eyelid Hordeolum Externum
Spastic Hemiplegia	Spastic Hemiplegic Cerebral Palsy Hemiplegic Cerebral Palsy Congenital Hemiplegia Hemiplegic Infantile Cerebral Palsy Cerebral Palsy Spastic Hemiplegic Spastic Hemiplegia Cerebral Palsy Hemiplegia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00195	ACRV1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20359	Acrv1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26868	Acrv1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACRV1	VGNC	VGNC:37528
Bos taurus	ACRV1	VGNC	VGNC:25559
Rattus norvegicus	ACRV1	RGD	RGD:620153
Mus musculus	ACRV1	MGD	MGI:104590
Macaca mulatta	ACRV1	VGNC	VGNC:99536
Others	ACRV1	NCBI