BIRC6 - baculoviral IAP repeat containing 6 Gene

Also Known as BRUCE; APOLLON

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57448

About BIRC6

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,357,023-32,618,878 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 7 paralogues and is associated with 115 phenotypes. Ubiquitous expression in thyroid (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues.

Summary

This gene encodes a protein with a BIR (baculoviral inhibition of Apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits Apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

BIRC6 Products (2)

mRNA Protein Name
NM_001378125.1 NP_001365054.1 baculoviral IAP repeat-containing protein 6 isoform 2
NM_016252.4 NP_057336.3 baculoviral IAP repeat-containing protein 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables cysteine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
15200957 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14765125 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
15200957 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15200957 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
14765125 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
18329369 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in endosome IDA
IDA: Inferred from direct assay
18329369 GOA
located in microtubule organizing center IDA
IDA: Inferred from direct assay
18329369 GOA
located in midbody IDA
IDA: Inferred from direct assay
18329369 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
18329369 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
18329369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC6 Protein Structure

BIR

BIR: Inhibitor of Apoptosis domain (289 - 359)

BIRC6

BIRC6: Baculoviral IAP repeat-containing protein 6 (3462 - 3618)

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (4577 - 4733)

  • 0
  • 800
  • 1600
  • 2400
  • 3200
  • 4000
  • 4857 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 6

  • BIR repeat-containing ubiquitin-conjugating enzyme

BIRC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
BIRC6 Q9NR09 EXOC4 Homo sapiens Q96A65
IF
18329369
Intra
BIRC6 Q9NR09 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
18329369
Intra
BIRC6 Q9NR09 PLK1 Homo sapiens P53350
Anti Bait CoIP
18329369
Intra
BIRC6 Q9NR09 PLK1 Homo sapiens P53350
IF
18329369
Intra
BIRC6 Q9NR09 MAP2K1 Homo sapiens Q02750
Anti Bait CoIP
18329369
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Hypoplastic Left Heart Syndrome

  • Hlhs

  • Heart, Hypoplastic Left, Syndrome

  • Hypoplasia Of The Left Heart

  • Left Heart Hypoplasia Syndrome

  • Hlhs - [Hypoplastic Left Heart Syndrome]

  • Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome

  • Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle

  • Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia

  • Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome

  • Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01514 BIRC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20370 Birc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26880 Birc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BIRC6 VGNC VGNC:26502
Rattus norvegicus BIRC6 RGD RGD:1307247
Felis catus BIRC6 VGNC VGNC:80031
Mus musculus BIRC6 MGD MGI:1276108
Canis familiaris BIRC6 VGNC VGNC:38462
Macaca mulatta BIRC6 VGNC VGNC:81365
Others BIRC6 NCBI