Vps11 - VPS11, CORVET/HOPS core subunit Gene

Also Known as 1200011A11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71732

Summary

Predicted to enable several functions, including protein-macromolecule adaptor activity; syntaxin binding activity; and ubiquitin protein Ligase activity. Acts upstream of or within toxin transport. Located in actin filament; early endosome; and presynaptic active zone. Part of AP-3 adaptor complex and CORVET complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]

Vps11 Products (2)

mRNA Protein Name
NM_001357393.1 NP_001344322.1 vacuolar protein sorting-associated protein 11 homolog isoform 2
NM_027889.2 NP_082165.1 vacuolar protein sorting-associated protein 11 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
14668490 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of AP-3 adaptor complex IDA
IDA: Inferred from direct assay
21411634 MGI
part of CORVET complex IDA
IDA: Inferred from direct assay
25266290 MGI
located in actin filament IDA
IDA: Inferred from direct assay
14668490 MGI
located in early endosome IDA
IDA: Inferred from direct assay
14668490 MGI
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
17027648 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 11 homolog

  • vacuolar protein sorting 11

Vps11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Vps11 Q91W86 VIPAS39 Homo sapiens Q9H9C1
Anti Bait CoIP
19109425
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15671 VPS11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps11 NCBI NCBI:55823