EEPD1 - endonuclease/exonuclease/phosphatase family domain containing 1 Gene

Also Known as HSPC107

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80820

About EEPD1

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,153,254-36,301,538 (from NCBI)

This gene has 5 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in fat (RPKM 7.4), brain (RPKM 4.8) and 23 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in positive regulation of Cholesterol efflux. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EEPD1 Products (1)

mRNA Protein Name
NM_030636.3 NP_085139.2 endonuclease/exonuclease/phosphatase family domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of cholesterol efflux IMP
IMP: Inferred from mutant phenotype
28082258 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
28082258 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEPD1 Protein Structure

HHH_3

HHH_3: Helix-hairpin-helix motif (35 - 97)

HHH_3

HHH_3: Helix-hairpin-helix motif (136 - 195)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (264 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
Protein Preferred Names Protein Names

endonuclease/exonuclease/phosphatase family domain-containing protein 1

EEPD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
EEPD1 Q7L9B9 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Prey Pooling
32296183
Intra
EEPD1 Q7L9B9 GRIP1 Homo sapiens Q9Y3R0-3
Validated Y2H
32296183
Intra
EEPD1 Q7L9B9 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meninges Sarcoma

  • Meningeal Sarcoma

  • Sarcoma Of Meninges

  • Meningothelial Sarcoma

  • Leptomeningeal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04183 EEPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20916 Eepd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27433 Eepd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EEPD1 VGNC VGNC:28338
Canis familiaris EEPD1 VGNC VGNC:40212
Rattus norvegicus EEPD1 RGD RGD:1307401
Felis catus EEPD1 VGNC VGNC:61736
Mus musculus EEPD1 MGD MGI:1914734
Macaca mulatta EEPD1 VGNC VGNC:72085
Others EEPD1 NCBI