Giffonin P
Giffonin P is a selective inhibitor targeting α-glucosidase with an IC50 of 55.3 μM. Giffonin P delays carbohydrate hydrolysis and glucose absorption, exerting anti-hyperglycemic activity. Giffonin P reduces postprandial blood glucose levels and is primarily used in research on type 2 diabetes.
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- CAS. Nr.: 1830306-93-8
- Formel: C19H22O7
- Molecular Weight:362.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | EC50 |
>150 μM
Compound: 7
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Cytotoxicity against human U2OS cells expressing wild-type p53 after 24 hrs by crystal violet-staining based spectrophotometric assay
Cytotoxicity against human U2OS cells expressing wild-type p53 after 24 hrs by crystal violet-staining based spectrophotometric assay
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[PMID: 26606246] |
Chemical Information
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CAS. Nr. 1830306-93-8
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Molecular Weight 362.37
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Formel C19H22O7
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SMILES
OC(C=C1)=C(C=C1C[C@H]([C@@H](C2O)O)O)C(C=C3C[C@@H]([C@@H]2O)O)=C(C=C3)O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Masullo M, et al. Giffonins J-P, Highly Hydroxylated Cyclized Diarylheptanoids from the Leaves of Corylus avellana Cultivar "Tonda di Giffoni". J Nat Prod. 2015 Dec 24;78(12):2975-82. [Content Brief]
[2]. Masullo M, et al. Corylus avellana: A Source of Diarylheptanoids With α-Glucosidase Inhibitory Activity Evaluated by in vitro and in silico Studies. Front Plant Sci. 2022 Feb 14;13:805660. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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