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Art. -Nr.: HY-122757

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Hydrazinocurcumin

(Synonyms: Curcumin pyrazole)

Hydrazinocurcumin (Curcumin pyrazole) is a potent endothelial cell proliferation inhibitor (IC₅₀=520 nM). Hydrazinocurcumin disrupts angiogenic signaling pathways and inhibits endothelial cell migration and tube formation, exerting anti-angiogenic activity. Hydrazinocurcumin is promising for research of tumor angiogenesis inhibition, metastatic cancer, and vascular-dependent diseases such as retinopathies.

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CAS. Nr.: 131068-23-0
Formel: C₂₁H₂₀N₂O₄
Molecular Weight:364.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Hydrazinocurcumin Chemical Structure

CAS. Nr.: 131068-23-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	19.4 μM Compound: 1	Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography	[PMID: 19128977]
Ehrlich	ED₅₀	100 mM Compound: 10	Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay Cytotoxicity against Mus musculus (mouse) EAC assessed as cell viability by trypan blue exclusion assay	10.1007/s00044-009-9199-3
HaCaT	IC₅₀	16.2 μM Compound: 5	Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay	[PMID: 24920381]
LNCaP	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24920381]
LNCaP	IC₅₀	3.4 μM Compound: 12	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF-10A	IC₅₀	>50 μM Compound: 12	Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay Antiproliferative activity against human MCF10A cells after 72 hrs by MTT assay	[PMID: 19249204]
MCF7	IC₅₀	4.19 μM Compound: 12	Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]
MCF7	IC₅₀	5.9 μM Compound: 12	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 19249204]
MDA-MB-231	IC₅₀	6.6 μM Compound: 12	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 19249204]
PBMC	IC₅₀	>50 μM Compound: 5	Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay	[PMID: 24920381]
PC-3	IC₅₀	5.6 μM Compound: 12	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 19249204]
SK-BR-3	IC₅₀	0.258 μM Compound: 12	Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS-PMS assay	[PMID: 19019687]

Chemical Information

CAS. Nr. 131068-23-0
Molecular Weight 364.39
Formel C₂₁H₂₀N₂O₄
SMILES

OC1=CC=C(/C=C/C2=NNC(/C=C/C3=CC=C(O)C(OC)=C3)=C2)C=C1OC
Synonyms

Curcumin pyrazole
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shim JS, et al. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation. Bioorg Med Chem. 2002 Sep;10(9):2987-92. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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