Hydroxylamine hydrochloride
Based on 2 publication(s) in Google Scholar
Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N2O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity.
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- Reinheit: 99.5%
- CAS. Nr.: 5470-11-1
- Formel: ClH4NO
- Molecular Weight:69.49
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Speicherung:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Hydroxylamine hydrochloride
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Biologische Aktivität
Hydroxylamine hydrochloride (1 mM) inhibits the activity of MAO for 99.8%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 5470-11-1
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Appearance Solid
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Molecular Weight 69.49
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Formel ClH4NO
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Color White to off-white
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SMILES
NO.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (2)
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Journal Impact Factor
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Most Recent
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Research (Wash D C)
EVA1A Regulates Hepatic Lipid Homeostasis by Modulating CD36 Expression and Its Palmitoylation. [Abstract]2025 Nov 25:8:1001. PMID: 41306774 -
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (1439.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (35.98 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (35.98 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (784 KB)
- English - EN (784 KB)
- Français - FR (784 KB)
- Deutsch - DE (784 KB)
- Norwegian - NO (784 KB)
- Español - ES (784 KB)
- Swedish - SV (784 KB)
- Italian - IT (784 KB)
- Korean - KR (784 KB)
- Portuguese - PT (784 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Roh JH, et al. Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12. Biosci Biotechnol Biochem. 1994 Sep;58(9):1652-6. [Content Brief]
[2]. Soler-Jofra A, et al. Hydroxylamine and the nitrogen cycle: A review. Water Res. 2021 Feb 15;190:116723. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 14.3906 mL | 71.9528 mL | 143.9056 mL | 359.7640 mL |
| 5 mM | 2.8781 mL | 14.3906 mL | 28.7811 mL | 71.9528 mL | |
| 10 mM | 1.4391 mL | 7.1953 mL | 14.3906 mL | 35.9764 mL | |
| 15 mM | 0.9594 mL | 4.7969 mL | 9.5937 mL | 23.9843 mL | |
| 20 mM | 0.7195 mL | 3.5976 mL | 7.1953 mL | 17.9882 mL | |
| 25 mM | 0.5756 mL | 2.8781 mL | 5.7562 mL | 14.3906 mL | |
| 30 mM | 0.4797 mL | 2.3984 mL | 4.7969 mL | 11.9921 mL | |
| 40 mM | 0.3598 mL | 1.7988 mL | 3.5976 mL | 8.9941 mL | |
| 50 mM | 0.2878 mL | 1.4391 mL | 2.8781 mL | 7.1953 mL | |
| 60 mM | 0.2398 mL | 1.1992 mL | 2.3984 mL | 5.9961 mL | |
| 80 mM | 0.1799 mL | 0.8994 mL | 1.7988 mL | 4.4971 mL | |
| 100 mM | 0.1439 mL | 0.7195 mL | 1.4391 mL | 3.5976 mL |
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