JH-LPH-28
Based on 1 Customer Validation
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.50%
- CAS. Nr.: 2414592-36-0
- Formel: C21H21F4N3O3S
- Molecular Weight:471.47
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
JH-LPH-28 displays IC50 values of 0.11 μM against K. pneumoniae LpxH and 0.083 μM against E. coli LpxH, respectively[1].
JH-LPH-28 potently inhibits bacterial growth at 2.8 μg/mL and displayes a MIC value of 1.6 μg/mL against wild-type K. pneumoniae (ATCC 10031)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2414592-36-0
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Appearance Solid
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Molecular Weight 471.47
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Formel C21H21F4N3O3S
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Color White to off-white
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SMILES
CC(N1CCC2=C1C=CC(S(=O)(N3CCN(C4=CC(F)=CC(C(F)(F)F)=C4)CC3)=O)=C2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 12.5 mg/mL (26.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1210 mL | 10.6051 mL | 21.2103 mL | 53.0256 mL |
| 5 mM | 0.4242 mL | 2.1210 mL | 4.2421 mL | 10.6051 mL | |
| 10 mM | 0.2121 mL | 1.0605 mL | 2.1210 mL | 5.3026 mL | |
| 15 mM | 0.1414 mL | 0.7070 mL | 1.4140 mL | 3.5350 mL | |
| 20 mM | 0.1061 mL | 0.5303 mL | 1.0605 mL | 2.6513 mL | |
| 25 mM | 0.0848 mL | 0.4242 mL | 0.8484 mL | 2.1210 mL |
JH-LPH-28 Related Classifications
HY-130837 Related Classifications
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