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Art. -Nr.: HY-208737

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KHK-IN-8

KHK-IN-8 is a selective KHK inhibitor, with an IC₅₀ of 13.0 nM against hKHK-C and an IC₅₀ of 22.7 nM against hKHK-A. KHK-IN-8 is applicable to research on non-alcoholic steatohepatitis, type 2 diabetes and obesity.

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CAS. Nr.: 3108075-72-2
Formel: C₂₂H₂₄F₃N₅O₂
Molecular Weight:447.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KHK-IN-8 Chemical Structure

CAS. Nr.: 3108075-72-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

hKHK-C

13.0 nM (IC₅₀)

hKHK-A

22.7 nM (IC₅₀)

Alle Ketohexokinase Isoform-spezifische Produkte anzeigen :

KHK-A
KHK-C

In Vitro

KHK-IN-8 potently inhibits recombinant human KHK-C with an IC₅₀ of 13.0 nM^[1].
KHK-IN-8 has an apparent permeability of 23 × 10^-6 cm/sec in a Caco-2 cell assay^[1].
KHK-IN-8 inhibits F1P production in HepG2 cells with an IC₅₀ of 156 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3108075-72-2
Molecular Weight 447.45
Formel C₂₂H₂₄F₃N₅O₂
SMILES

CN([C@H]1CCN(C2=NC(NC3=CC(CCC(O)=O)=CC=C3)=C(C#N)C(C(F)(F)F)=C2)C1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Heine N, et al. Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability. Bioorganic & medicinal chemistry letters. 2024 Nov 01;112:129930. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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KHK-IN-8

Alle Ketohexokinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

KHK-IN-8 Related Classifications

HY-208737 Related Classifications