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Art. -Nr.: HY-103639

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M62812 free base

M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 613262-61-6
Formel: C₁₃H₁₁N₃OS
Molecular Weight:257.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

M62812 free base Chemical Structure

CAS. Nr.: 613262-61-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	7 μM Compound: 23	Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay	[PMID: 18828583]
PBMC	IC₅₀	3 μM Compound: 23	Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation	[PMID: 18828583]

In Vitro

M62812 (0-10 μg/ml) suppresses LPS-induced upregulation of inflammatory cytokines, adhesion molecules and procoagulant activity in human vascular endothelial cells and peripheral mononuclear cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model^[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

D-galactosamine-sensitized endotoxin shock mouse model^[1]
Dosage:

10-20 mg/kg
Administration:

Single intravenous administration
Result:

Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.

Animal Model:

A cecal ligation and puncture mouse model^[1]
Dosage:

20 mg/kg
Administration:

Intravenous administration; Everyday
Result:

Reduced mortality in a murine cecal ligation and puncture model.

Related Protocols :

LPS-Induced Endotoxemia/Systemic Inflammation

Chemical Information

CAS. Nr. 613262-61-6
Molecular Weight 257.31
Formel C₁₃H₁₁N₃OS
SMILES

NC1=NSC2=C1C=CC(OC3=CC=CC=C3N)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569(3):237-243. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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