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Art. -Nr.: HY-185453

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Mtb-IN-14

Mtb-IN-14 is a Mycobacterium tuberculosis (Mtb) malate synthase (GlcB) inhibitor with an IC₅₀ of 0.24 μM. Mtb-IN-14 inhibits growth of Mycobacterium tuberculosis. Mtb-IN-14 can be used for the research of tuberculosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1224740-41-3
Formel: C₁₀H₇FO₄
Molecular Weight:210.16

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mtb-IN-14 Chemical Structure

CAS. Nr.: 1224740-41-3

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Mtb-IN-14 (Compound 2) (20 min) potently inhibits purified C619A mutant Mtb malate synthase (GlcB) with an IC₅₀ of 0.24 μM^[1].
Mtb-IN-14 has a half-life of 12 days in cell growth media or buffer solutions^[1].
Mtb-IN-14 has a λ_max of 333 nm, reflecting reduced structural conjugation compared to the parent PDKA compound^[1].
Mtb-IN-14 inhibits growth of Mtb mc²-7000 with an MIC₉₉ of >200 μM in acetate-supplemented media and 200 μM in dextrose-supplemented media^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1224740-41-3
Molecular Weight 210.16
Formel C₁₀H₇FO₄
SMILES

OC(/C(O)=C/C(C1=C(C=CC=C1)F)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Krieger IV, et al. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem Biol. 2012;19(12):1556-1567. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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