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Art. -Nr.: HY-180244

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P2L-003

P2L-003 is a selective PAR2 antagonist with an IC₅₀ of 0.62 μM in HT-29 cells. P2L-003 blocks PAR2-mediated Ca²⁺ mobilization without affecting PAR1, PAR4, or ATP-mediated signaling and dose-dependently suppresses the downstream MAPK signaling cascades, including ERK1/2 and p38 phosphorylation. P2L-003 can be used for colon cancer research.

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CAS. Nr.: 1359416-20-8
Formel: C₂₃H₂₅ClN₄O₃S
Molecular Weight:472.99

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

P2L-003 Chemical Structure

CAS. Nr.: 1359416-20-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Protease Activated Receptor (PAR) Isoform-spezifische Produkte anzeigen :

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

In Vitro

P2L-003 (0-30 μM, 24 h) does not compromise cell proliferation in HT-29 cells^[1].
P2L-003 (3-30 μM, 24 h) not only blocks PAR2-mediated Ca2+ mobilization but also suppresses downstream ERK1/2 and p38 signaling cascades in a concentration-dependent manner in HT-29 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HT-29 cells
Concentration:

0, 10 and 30 μM
Incubation Time:

24 h
Result:

Remained above 90 % even at the highest tested concentration of 30 μM.

Western Blot Analysis^[1]

Cell Line:

HT-29 cells
Concentration:

3, 10 and 30 μM
Incubation Time:

24 h
Result:

Reduced the phosphorylation levels of both ERK1/2 and p38 relative to their total protein levels in a dose-dependent manner^[1].
Inhibited PAR2-induced MAPK pathway activation^[1].

Chemical Information

CAS. Nr. 1359416-20-8
Molecular Weight 472.99
Formel C₂₃H₂₅ClN₄O₃S
SMILES

ClC1=C(CS(N2CC(C(CN(C(C)=O)C3=CC=CC=C3)=NN4C)=C4CC2)(=O)=O)C=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Park J, et al. Discovery of PAR2 antagonists through fragment molecular orbital-based hotspot analysis and allosteric sodium site dynamics simulations. Bioorg Chem. 2025 Dec;167:109285. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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P2L-003

Alle Protease Activated Receptor (PAR) Isoform-spezifische Produkte anzeigen

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

P2L-003 Related Classifications

HY-180244 Related Classifications