Art. -Nr.: HY-138558

PAR-2-IN intermediate-1

Name: PAR-2-IN intermediate-1
Brand: MedChemExpress
SKU: HY-138558
Price: 36.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

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PAR-2-IN intermediate-1 is a drug intermediate that can be used to synthesize inhibitors of the PAR-2 signaling pathway.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.92%
CAS. Nr.: 1690176-75-0
Formel: C₁₂H₁₄ClN₃O₂
Molecular Weight:267.71

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PAR-2-IN intermediate-1 Chemical Structure

CAS. Nr.: 1690176-75-0

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PAR-2-IN intermediate-1 is a drug intermediate that can be used to synthesize inhibitors of the PAR-2 signaling pathway^[1].

In Vitro

PAR-2-IN intermediate-1 (Compound Intermediate O) can be used to synthesize inhibitors of the PAR-2 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1690176-75-0
Appearance Solid
Molecular Weight 267.71
Formel C₁₂H₁₄ClN₃O₂
Color White to light yellow
SMILES

O=C(C1=CN2N=C(Cl)C=C(C(C)(C)C)C2=N1)OC
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Autophagy

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [Abstract]

2025 Oct;21(10):2130-2147. PMID: 40205686
Cell Biochem Funct

Protease-Activated Receptor 2 Activation Provokes an Increase in Intracellular Calcium and Serotonin Secretion in a Human Enteroendocrine Cell Line. [Abstract]

2025 Nov;43(11):e70132. PMID: 41139931

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (311.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7354 mL

18.6769 mL

37.3539 mL

5 mM

0.7471 mL

3.7354 mL

7.4708 mL

10 mM

0.3735 mL

1.8677 mL

3.7354 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (7.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Luc J. Farmer, et al. Imidazopyridazines useful as inhibitors of the par-2 signaling pathway. WO2015048245A1. 2016-03-25

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7354 mL	18.6769 mL	37.3539 mL	93.3846 mL
	5 mM	0.7471 mL	3.7354 mL	7.4708 mL	18.6769 mL
	10 mM	0.3735 mL	1.8677 mL	3.7354 mL	9.3385 mL
	15 mM	0.2490 mL	1.2451 mL	2.4903 mL	6.2256 mL
	20 mM	0.1868 mL	0.9338 mL	1.8677 mL	4.6692 mL
	25 mM	0.1494 mL	0.7471 mL	1.4942 mL	3.7354 mL
	30 mM	0.1245 mL	0.6226 mL	1.2451 mL	3.1128 mL
	40 mM	0.0934 mL	0.4669 mL	0.9338 mL	2.3346 mL
	50 mM	0.0747 mL	0.3735 mL	0.7471 mL	1.8677 mL
	60 mM	0.0623 mL	0.3113 mL	0.6226 mL	1.5564 mL
	80 mM	0.0467 mL	0.2335 mL	0.4669 mL	1.1673 mL
	100 mM	0.0374 mL	0.1868 mL	0.3735 mL	0.9338 mL

Bioz

Keywords

PAR-2-IN intermediate-1

2 Cited Publications

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PAR-2-IN intermediate-1

Publications Citing Use of MedChemExpress (MCE) PAR-2-IN intermediate-1