PDE4-IN-15
PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC50 = 0.17 μM) and has anti-TNF-α activity (EC50 = 0.19 μM). PDE4-IN-15 has a good skin permeability.
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- CAS. Nr.: 3034837-89-0
- Formel: C23H30O6
- Molecular Weight:402.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
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PDE4 |
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Cell Line
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Type | Value | Description | References |
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| PBMC | CC50 |
>180 μM
Compound: 7b-1
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Cytotoxicity against human PBMC cells by MTT assay
Cytotoxicity against human PBMC cells by MTT assay
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[PMID: 38489246] |
| PBMC | EC50 |
0.19 μM
Compound: 7b-1
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Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
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[PMID: 38489246] |
Chemical Information
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CAS. Nr. 3034837-89-0
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Molecular Weight 402.48
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Formel C23H30O6
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SMILES
OC[C@H]1C2=C(O[C@@H]1C3=CC(OCC)=C(C=C3)OC)C(OCC)=CC(CCCO)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PDE4-IN-15 Related Classifications
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