CD99/MIC2
CD99 is a 32 kDa type I transmembrane glycoprotein encoded by the MIC2 gene, which lies in the pseudoautosomal region of the sex chromosomes and escapes X inactivation. It engages in homophilic adhesion and participates in T cell costimulation, thymocyte positive selection, and leukocyte diapedesis. CD99 is strongly and diffusely expressed by Ewing sarcoma and primitive neuroectodermal tumors, making membrane CD99 a key diagnostic immunohistochemical marker for this group. It is also found on pancreatic beta cells, ovarian granulosa cells, and many lymphoid cells. Antibodies against CD99 have been explored to modulate immune responses and as therapeutic leads in Ewing sarcoma.
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CD99/MIC2 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
