PKD
The PKD group encodes protein kinase D enzymes, a CAMK-branch family defined by an N-terminal tandem C1 phorbol ester and diacylglycerol-binding domain, a central pleckstrin homology domain, and a C-terminal catalytic domain. Novel PKC isoforms activate PKD by phosphorylating its activation loop after diacylglycerol recruitment to membranes. PKD1, PKD2, and PKD3 regulate vesicular trafficking from the Golgi, secretory transport, cell migration, and proliferation. They phosphorylate class IIa histone deacetylases, linking hypertrophic and immune signals to the nucleus, and control insulin secretion and lymphocyte trafficking. Dysregulated PKD signaling contributes to cardiac hypertrophy, inflammatory disease, and multiple cancers, and PKD inhibitors are under preclinical investigation.
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PKD Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
