YANK
YANK, the STK32A, STK32B, and STK32C genes, forms the least-characterized branch of the AGC family, with three mammalian members expressed prominently in brain and testis. Structurally they combine an N-terminal PH-like domain with an AKT-like kinase domain; unlike AKT, however, YANK activation is reported to be largely PDK1-independent, and no physiological substrates have been established. Functional studies implicate YANK1 in neuronal and epithelial cell morphology, with expression linked to glioma proliferation, and YANK2 in sperm flagellar function and male fertility, where it is a candidate downstream effector of AKT in sperm motility. Because specific activators and substrates remain unresolved, recombinant YANK proteins are used chiefly for kinase profiling, phosphoproteomic substrate discovery, and antibody development targeting this orphan AGC branch.
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YANK Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
