PV1162
PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy.
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- CAS. Nr.: 1093793-11-3
- Formel: C21H24N6O2
- Molecular Weight:392.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Chk1 59000 nM (IC50) |
Chk2 0.29 nM (IC50) |
Chemical Information
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CAS. Nr. 1093793-11-3
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Molecular Weight 392.45
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Formel C21H24N6O2
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SMILES
O=C(C(N1)=CC2=C1C=CC(OC)=C2)NC3=CC=C(/C(CCC)=N/NC(N)=N)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PV1162 Related Classifications
HY-164523 Related Classifications
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