Art. -Nr.: HY-113068

(rel)-β-Tocopherol

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(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity.

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Reinheit: 99.91%
CAS. Nr.: 148-03-8
Formel: C₂₈H₄₈O₂
Molecular Weight:416.69

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

(rel)-β-Tocopherol Chemical Structure

CAS. Nr.: 148-03-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity^[1].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

β-Tocopherol (50 μM, 48 h) slightly inhibits A7r5 (10% inhibition) and CHO cell (20% inhibition) proliferation, while showing no inhibition against HeLa cells^[2].
β-Tocopherol (50 μM, 24 h) inhibits PMA (HY-18739)-induced adhesion of human erythroleukemia (HEL) cells (11% inhibition), and inhibits the expression of integrins α4 and α5 on cell surface^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

A7r5, CHO, HeLa cells
Concentration:

50 μM
Incubation Time:

48 h
Result:

Slightly inhibited A7r5 and CHO cell proliferation.
Did not inhibit HeLa cell proliferation.

Chemical Information

CAS. Nr. 148-03-8
Appearance Solid-Liquid Mixture
Molecular Weight 416.69
Formel C₂₈H₄₈O₂
Color Colorless to off-white
SMILES

OC1=CC(C)=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C1C
Structure Classification
- Phenols
- Monophenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 50 mg/mL (119.99 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3999 mL

11.9993 mL

23.9987 mL

5 mM

0.4800 mL

2.3999 mL

4.7997 mL

10 mM

0.2400 mL

1.1999 mL

2.3999 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (3.00 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (913 KB)
- English - EN (913 KB)
- Français - FR (913 KB)
- Deutsch - DE (913 KB)
- Norwegian - NO (913 KB)
- Español - ES (913 KB)
- Swedish - SV (913 KB)
- Italian - IT (913 KB)
- Korean - KR (913 KB)
- Portuguese - PT (913 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. F. Bergel, et al. Studies on vitamin E. Part III. Observations on the structure of α- and β-tocopherol.

[2]. Fazzio A, et al. The Effect of α‐Tocopherol and Β‐tocopherol on Proliferation, Protein Kinase C Activity and Gene Expression in Different Cell Lines. IUBMB Life 1997, 41 (1), 93–101.

[3]. Breyer I, et al. Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins. Free Radic Biol Med. 2001 Jun 15;30(12):1381-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	2.3999 mL	11.9993 mL	23.9987 mL	59.9966 mL
	5 mM	0.4800 mL	2.3999 mL	4.7997 mL	11.9993 mL
	10 mM	0.2400 mL	1.1999 mL	2.3999 mL	5.9997 mL
	15 mM	0.1600 mL	0.8000 mL	1.5999 mL	3.9998 mL
	20 mM	0.1200 mL	0.6000 mL	1.1999 mL	2.9998 mL
	25 mM	0.0960 mL	0.4800 mL	0.9599 mL	2.3999 mL
	30 mM	0.0800 mL	0.4000 mL	0.8000 mL	1.9999 mL
	40 mM	0.0600 mL	0.3000 mL	0.6000 mL	1.4999 mL
	50 mM	0.0480 mL	0.2400 mL	0.4800 mL	1.1999 mL
	60 mM	0.0400 mL	0.2000 mL	0.4000 mL	0.9999 mL
	80 mM	0.0300 mL	0.1500 mL	0.3000 mL	0.7500 mL
	100 mM	0.0240 mL	0.1200 mL	0.2400 mL	0.6000 mL

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(rel)-β-Tocopherol

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(rel)-β-Tocopherol

Metabolism/Protease Compound Library

Natural Product Library

Antioxidant Compound Library

Medicine Food Homology Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Anti-Blood Cancer Compound Library

Food-Sourced Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Metabolic Enzyme Compound Library

Animal-Sourced Natural Product Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Vitamin Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(rel)-β-Tocopherol Related Classifications

HY-113068 Related Classifications