β-Tocopherol
Based on 1 Customer Validation
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.
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- Reinheit : 99.64%
- CAS. Nr.: 16698-35-4
- Formel: C28H48O2
- Molecular Weight:416.69
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-108693
β-TocotrienolAntioxidant -
HY-108694
γ-TocotrienolVitamin E -
HY-101461
Methyl-β-cyclodextrinCholesterol-removing Agent -
HY-122778
δ-TocotrienolVitamin E -
HY-129459
α-TocotrienolEndogenous Metabolite -
HY-133680R
β-Tocopherol (Standard)Vitamin E Analogue -
HY-D0168
OrcinolMelanogenesis Inhibitor -
HY-101445A
(R)-TroloxTyrosinase Inhibitor -
HY-113068
(rel)-β-Tocopherolβ-Tocopherol Isomer -
HY-113068R
(rel)-β-Tocopherol (Standard)Tyrosinase Inhibitor -
HY-101445AR
(R)-Trolox (Standard)Tyrosinase Inhibitor
Biologische Aktivität
Beschreibung
In Vitro
β-Tocopherol (250 µg/mL, 72 h) inhibits the expression of tyrosinase and tyrosinase-related protein-2 (TRP-2), inhibits the melanin synthesis (250 µg/mL, 28% inhibition rate) without significant cytotoxicity in cell B16[3].
β-Tocopherol (50 µM, 24 h) inhibits PMA (HY-18739)-induced adhesion of human erythroleukemia cells (HEL), and inhibits the expression of integrins α4 and α5 on cell surface[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 16698-35-4
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Appearance Liquid (Density: 0.933±0.06 g/cm3)
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Molecular Weight 416.69
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Formel C28H48O2
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Color Colorless to light yellow
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SMILES
OC1=CC(C)=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C1C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (239.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Azzi A, et, al. d-alpha-tocopherol control of cell proliferation. Mol Aspects Med. 1993; 14(3): 265-71. [Content Brief]
[2]. Tasinato A, et, al. d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26): 12190-4. [Content Brief]
[3]. Kamei Y, et, al. Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. Cytotechnology. 2009 Apr; 59(3): 183-90. [Content Brief]
[4]. Breyer I, et al., Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins. Free Radic Biol Med. 2001 Jun 15;30(12):1381-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3999 mL | 11.9993 mL | 23.9987 mL | 59.9966 mL |
| 5 mM | 0.4800 mL | 2.3999 mL | 4.7997 mL | 11.9993 mL | |
| 10 mM | 0.2400 mL | 1.1999 mL | 2.3999 mL | 5.9997 mL | |
| 15 mM | 0.1600 mL | 0.8000 mL | 1.5999 mL | 3.9998 mL | |
| 20 mM | 0.1200 mL | 0.6000 mL | 1.1999 mL | 2.9998 mL | |
| 25 mM | 0.0960 mL | 0.4800 mL | 0.9599 mL | 2.3999 mL | |
| 30 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 1.9999 mL | |
| 40 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.4999 mL | |
| 50 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.1999 mL | |
| 60 mM | 0.0400 mL | 0.2000 mL | 0.4000 mL | 0.9999 mL | |
| 80 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7500 mL | |
| 100 mM | 0.0240 mL | 0.1200 mL | 0.2400 mL | 0.6000 mL |
β-Tocopherol Related Classifications
HY-133680 Related Classifications
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