(rel)-β-Tocopherol
Based on 1 Customer Validation
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 148-03-8
- Formula: C28H48O2
- Molecular Weight:416.69
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human Endogenous Metabolite |
β-Tocopherol (50 μM, 48 h) slightly inhibits A7r5 (10% inhibition) and CHO cell (20% inhibition) proliferation, while showing no inhibition against HeLa cells[2].
β-Tocopherol (50 μM, 24 h) inhibits PMA (HY-18739)-induced adhesion of human erythroleukemia (HEL) cells (11% inhibition), and inhibits the expression of integrins α4 and α5 on cell surface[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A7r5, CHO, HeLa cells
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Concentration:50 μM
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Incubation Time:48 h
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Result:Slightly inhibited A7r5 and CHO cell proliferation.
Did not inhibit HeLa cell proliferation.
Chemical Information
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CAS No. 148-03-8
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Appearance Solid-Liquid Mixture
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Molecular Weight 416.69
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Formula C28H48O2
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Color Colorless to off-white
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SMILES
OC1=CC(C)=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C1C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
Ethanol : 50 mg/mL (119.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.00 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (270 KB)
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SDS (913 KB)
- English - EN (913 KB)
- Français - FR (913 KB)
- Deutsch - DE (913 KB)
- Norwegian - NO (913 KB)
- Español - ES (913 KB)
- Swedish - SV (913 KB)
- Italian - IT (913 KB)
- Portuguese - PT (913 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3999 mL | 11.9993 mL | 23.9987 mL | 59.9966 mL |
| 5 mM | 0.4800 mL | 2.3999 mL | 4.7997 mL | 11.9993 mL | |
| 10 mM | 0.2400 mL | 1.1999 mL | 2.3999 mL | 5.9997 mL | |
| 15 mM | 0.1600 mL | 0.8000 mL | 1.5999 mL | 3.9998 mL | |
| 20 mM | 0.1200 mL | 0.6000 mL | 1.1999 mL | 2.9998 mL | |
| 25 mM | 0.0960 mL | 0.4800 mL | 0.9599 mL | 2.3999 mL | |
| 30 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 1.9999 mL | |
| 40 mM | 0.0600 mL | 0.3000 mL | 0.6000 mL | 1.4999 mL | |
| 50 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.1999 mL | |
| 60 mM | 0.0400 mL | 0.2000 mL | 0.4000 mL | 0.9999 mL | |
| 80 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7500 mL | |
| 100 mM | 0.0240 mL | 0.1200 mL | 0.2400 mL | 0.6000 mL |
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