country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-12730

Copy Link Print Information

RG7109

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1257830-82-2
Formel: C₂₇H₂₉N₃O₅S
Molecular Weight:507.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

RG7109 Chemical Structure

CAS. Nr.: 1257830-82-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

RG7109 is a non-nucleoside allosteric inhibitor of the hepatitis C virus NS5B polymerase. RG7109 inhibits HCV replication in replicon assays^[1]^[2].

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Viral Infection

RG7109 is a potent, equipotent inhibitor of GT-1a H77 and GT-1b Con1 HCV replicons, maintaining potency of ≤10 nM in 40% serum, with serum shifts of 3.8- to 9.4-fold^[1].
RG7109 retains potency against GT-1a and GT-1b NS5B isolates in transient replicon assays, with the greatest reduction in potency observed against the RO-38 isolate containing S556G^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1257830-82-2
Molecular Weight 507.60
Formel C₂₇H₂₉N₃O₅S
SMILES

CS(=O)(NC1=CC=C(C2=CC3=C(OC)C(C(C)(C)C)=CC(C4=CC=C(OC)NC4=O)=C3N=C2)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Talamas FX, et al. Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. Journal of medicinal chemistry. 2014 Mar 13;57(5):1914-31. [Content Brief]

[2]. de la Guardia C, et al. Antiviral Activity of Novel Quinoline Derivatives against Dengue Virus Serotype 2. Molecules (Basel, Switzerland). 2018 Mar 16;23(3):672.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen