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Art. -Nr.: HY-145287

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S-MGB-234

S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines.

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CAS. Nr.: 1970223-53-0
Formel: C₃₀H₃₂N₈O₄
Molecular Weight:568.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

S-MGB-234 Chemical Structure

CAS. Nr.: 1970223-53-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

Trypanosoma

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In Vitro

S-MGB-234 (compound 7) (69 hours) shows nontoxic to L6 cells with an EC₅₀ of 20.39 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S-MGB-234 (compound 7) provides total cure and no relapses in mice (cured/infected, 4/4), when treated with 2 applications of 50 mg/kg i.p.. Partial cure (1/4) is seen in mice treated with four daily applications of 10 mg/kg i.p., whilst only two applications of S-MGB-234 (compound 7) at 10 mg/kg i.p. gives no cure but prolongs survival relative to the untreated control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1970223-53-0
Molecular Weight 568.63
Formel C₃₀H₃₂N₈O₄
SMILES

O=C(C1=CC(NC(C2=CN=C(/C=C/C3=CC=C(C=C3)OC)C=C2)=O)=CN1C)NC4=CN(C)C(C(NCCC(N)=N)=O)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Giordani F, et al. Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [published correction appears in J Med Chem. 2021 Dec 23;64(24):18236]. J Med Chem. 2019;62(6):3021-3035. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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S-MGB-234

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

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Calculators

Help & FAQs

S-MGB-234 Related Classifications

HY-145287 Related Classifications