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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
454 Results for "
Localization
" in MedChemExpress (MCE) Product Catalog:
Products (454)
454 Results for "Localization" in MCE Product Catalog:
206
206 Publications Verification
Art. -Nr.: HY-D0079
CAS. Nr.: 104821-25-2
Synonyms: Hydroethidine; PD-MY 003
146
50
50 Cited Publications
Art. -Nr.: HY-D1533
CAS. Nr.: 1447815-38-4
28
Target:
Forschungsgebiete:
Dihydrorhodamine 123 (DHR 123) is a non-fluorescent reactive oxygen species (ROS) indicator. Dihydrorhodamine 123 is oxidized to fluorescent Rhodamine 123 (HY-D0816) within cells in the presence of reactive oxygen species and it localizes in mitochondria (Ex/Em = 515/536 nm).
28
28 Cited Publications
Art. -Nr.: HY-D1614
CAS. Nr.: 216434-81-0
Target:
Forschungsgebiete:
BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
17
17 Cited Publications
Synonyms: (-)-Epicatechol; Epicatechin; epi-Catechin
Category:
Anti-aging Endogenous metabolite Theaceae Extract Plant Flavonoids Sunscreen Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer
Target:
13
13 Cited Publications
Art. -Nr.: HY-D0986
CAS. Nr.: 115534-33-3
13
13 Cited Publications
Art. -Nr.: HY-B0002
CAS. Nr.: 99614-01-4
Synonyms: GR 38032 hydrochloride; SN 307 hydrochloride
Target:
Forschungsgebiete:
Ondansetron (GR 38032; SN 307) hydrochloride is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron hydrochloride exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .
13
Target:
Forschungsgebiete:
Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .
13
13 Cited Publications
Art. -Nr.: HY-B0002A
CAS. Nr.: 103639-04-9
Synonyms: GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate
Target:
Forschungsgebiete:
Ondansetron (GR 38032; SN 307) hydrochloride dehydrate is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron hydrochloride dehydrate exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride dehydrate can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .
12
12 Cited Publications
Art. -Nr.: HY-18676
CAS. Nr.: 2070015-22-2
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .
11
11 Cited Publications
Synonyms: GTP trisodium salt hydrate
11
9
9 Cited Publications
Art. -Nr.: HY-P99977
Target:
Forschungsgebiete:
8
8 Cited Publications
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals .
8
8 Cited Publications
Synonyms: GTP trisodium
7
7 Cited Publications
Art. -Nr.: HY-19979
CAS. Nr.: 339163-65-4
Target:
Forschungsgebiete:
RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research .
6
Target:
Forschungsgebiete:
Catalase, Aspergillus niger is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.
6
6 Cited Publications
5
5 Cited Publications
Synonyms: Nuc-H2O2 Probe
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
