sEH-IN-12
sEH-IN-12 is a potent soluble epoxide hydrolase (sEH) inhibitor with the property of inhibiting sEH activity. sEH-IN-12 was successfully used in the construction and selection of small molecule libraries, showing excellent biological activity. The development of sEH-IN-12 provides a new tool for drug discovery targeting sEH.
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- CAS. Nr.: 1883803-09-5
- Formel: C25H29N5O2
- Molecular Weight:431.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
2 nM
Compound: 16
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Competitive inhibition of N-terminal His-tagged human recombinant sEH expressed in insect Sf21 cells using Epoxy Fluor 7 as substrate preincubated for 15 mins followed by substrate addition measured for 20 mins by fluorescent intensity assay
Competitive inhibition of N-terminal His-tagged human recombinant sEH expressed in insect Sf21 cells using Epoxy Fluor 7 as substrate preincubated for 15 mins followed by substrate addition measured for 20 mins by fluorescent intensity assay
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[PMID: 26914744] |
Chemical Information
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CAS. Nr. 1883803-09-5
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Molecular Weight 431.53
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Formel C25H29N5O2
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SMILES
O=C(C1=CN=C(C=C1)C2=CC=CC(C(NC3CCCCC3)=O)=C2)N(C)CCN4N=CC=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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