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Art. -Nr.: HY-N12915

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SHP2-IN-29

SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with an IC₅₀ value of 0.18 μM. SHP2-IN-29 also has inhibitory activity against PTP1B and TCPTP, with IC₅₀ values of 4.27 and 4.74 μM, respectively.

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CAS. Nr.: 2130080-86-1
Formel: C₁₆H₂₀O₄
Molecular Weight:276.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

SHP2-IN-29 Chemical Structure

CAS. Nr.: 2130080-86-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	9.9 μM Compound: 13	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess assay	[PMID: 31012585]

Chemical Information

CAS. Nr. 2130080-86-1
Molecular Weight 276.33
Formel C₁₆H₂₀O₄
SMILES

O=C(O)C1=C(CC/C=C/C=C/CCC)C=C(O)C=C1O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
fungal strain F10Z1082
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sun W, et al. Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3382-3385. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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