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Art. -Nr.: HY-189605

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SMN modulator-1

SMN modulator-1 is an SMN2 mRNA splicing modulator. SMN modulator-1 increases the expression of full-length SMN (FL-SMN) mRNA by promoting the inclusion of exon 7 in the SMN2 gene. SMN modulator-1 can be used in research related to spinal muscular atrophy (SMA).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2407724-51-8
Formel: C₂₂H₂₃N₅O
Molecular Weight:373.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMN modulator-1 Chemical Structure

CAS. Nr.: 2407724-51-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

SMN modulator-1 (compound 80) upregulates FL-SMN mRNA expression levels in SMA patient-derived fibroblasts (GM03813), with relative expression levels of 100%-120% compared to the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS. Nr. 2407724-51-8
Molecular Weight 373.45
Formel C₂₂H₂₃N₅O
SMILES

O=C1C2=C(N=CN1C3CCN(CC3)C)C=CC(C4=CC5=NC(C)=CN5C=C4)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Fuji K, et al. PROPHYLACTIC OR THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY. WO 2020/004594 A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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