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Art. -Nr.: HY-P11083

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Xentry

Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .

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CAS. Nr.: 1352335-71-7
Formel: C₃₃H₆₀N₁₀O₈S
Molecular Weight:756.96

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Xentry Chemical Structure

CAS. Nr.: 1352335-71-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

Xentry (10 μM) penetrates adherent cells energy-dependently, including HepG2 (liver), C32 (melanoma), DU145 (prostate), H441 (lung), BT474 (breast), Cos (kidney), and Rin-m5F (pancreatic b-cell) cell lines, but not nonadherent resting blood cells^[1].
Xentry (10-20 μM, 4 h) conjugated to β-galactosidase is internalized by living HepG2 cells, and enters cells via a syndecan pathway^[1].
Xentry (1 h) effectively delivers antibodies and siRNA to melanoma cells, inducing apoptosis of B-raf-dependent melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cy7-labelled Xentry (2-20 μg/mL, i.v., single dose) is widely distributed in various tissues within 15 minutes, with a preferential accumulation in epithelial tissues (intestine, stomach, bronchus), and mainly remains in the liver and kidneys after 24 hours in Balb/c mice^[1].
TAMRA-labelled Xentry (2-100 μg/mL, i.v., single dose) successfully delivers the macromolecular complex to multiple tissues in Balb/c mice, specifically enriching in small intestinal epithelial cells and marginal sinus of the spleen^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1352335-71-7
Molecular Weight 756.96
Formel C₃₃H₆₀N₁₀O₈S
Sequence

Leu-Cys-Leu-Arg-Pro-Val-Gly
Sequence Shortening

LCLRPVG
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Montrose K, et al. Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs. Sci Rep. 2013;3:1661. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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