Cat. No.: HY-N2026

Propylparaben

(Synonyms: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury.

For research use only. We do not sell to patients.

Purity: 99.96%
CAS No.: 94-13-3
Formula: C₁₀H₁₂O₃
Molecular Weight:180.20

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Propylparaben Chemical Structure

CAS No.: 94-13-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

All Sodium Channel Isoforms :

All PI3K Isoforms :

All JNK Isoforms :

All Akt Isoforms :

In Vitro

Propylparaben shows weak estrogenic activity, with a potency approximately 30,000-fold less than 17β-estradiol^[1].
Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Propylparaben (0-1% in diet; dietary; continuous; 28 days) disrupts male reproductive function in immature rats, causing dose-dependent reductions in sperm parameters and serum testosterone^[1].
Propylparaben (7.5 mg/kg; p.o.; daily for 8 months) significantly alters the estrous cycle, hormone levels and ovarian reserve, and accelerated ovarian aging in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Crj:Wistar rats (male, 19-21 days old, 52.5 g) fed with slightly modified AIN93G diet^[1]
Dosage:

0; 0.01; 0.1; 1% in diet
Administration:

dietary; continuous; 28 days
Result:

Reduced final body weight slightly but significantly at 1.00% dietary concentration.
Decreased cauda epididymal sperm reserves and sperm concentrations in a dose-dependent manner.
Decreased daily sperm production (DSP) and sperm production efficiency in the testes in a dose-dependent manner.
Decreased serum testosterone concentration in a dose-dependent manner, with a significant reduction to 64.6% of the control value at the 1.00% dietary concentration.

Animal Model:

Cycling wild-type female Swiss mice^[5]
Dosage:

7.5 mg/kg
Administration:

p.o.; daily for 8 months
Result:

Significantly altered the estrous cycle, hormone levels and ovarian reserve.
Accelerated ovarian aging of female mice.

Chemical Information

CAS No. 94-13-3
Appearance Solid
Molecular Weight 180.20
Formula C₁₀H₁₂O₃
Color White to off-white
SMILES

O=C(OCCC)C1=CC=C(O)C=C1
Synonyms

Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate
Structure Classification
- Phenols
- Monophenols
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Ecotoxicol Environ Saf

A combined study of network-based prediction and in vitro experimental validation on the procarcinogenic mechanism of propylparaben in estrogen receptor-positive breast cancer cells. [Abstract]

2025 Dec 3:309:119504. PMID: 41344141

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (554.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.5494 mL

27.7469 mL

55.4939 mL

5 mM

1.1099 mL

5.5494 mL

11.0988 mL

10 mM

0.5549 mL

2.7747 mL

5.5494 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (11.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. S Oishi, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002 Dec;40(12):1807-13. [Content Brief]

[2]. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82. [Content Brief]

[3]. Ji X, et al. Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life Sci. 2004 Apr 30;74(24):3043-52. [Content Brief]

[4]. Yan W, et al. Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice. Ecotoxicol Environ Saf. 2022 Apr 15;235:113432. [Content Brief]

[5]. Gal A, et al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.5494 mL	27.7469 mL	55.4939 mL	138.7347 mL
	5 mM	1.1099 mL	5.5494 mL	11.0988 mL	27.7469 mL
	10 mM	0.5549 mL	2.7747 mL	5.5494 mL	13.8735 mL
	15 mM	0.3700 mL	1.8498 mL	3.6996 mL	9.2490 mL
	20 mM	0.2775 mL	1.3873 mL	2.7747 mL	6.9367 mL
	25 mM	0.2220 mL	1.1099 mL	2.2198 mL	5.5494 mL
	30 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6245 mL
	40 mM	0.1387 mL	0.6937 mL	1.3873 mL	3.4684 mL
	50 mM	0.1110 mL	0.5549 mL	1.1099 mL	2.7747 mL
	60 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	80 mM	0.0694 mL	0.3468 mL	0.6937 mL	1.7342 mL
	100 mM	0.0555 mL	0.2775 mL	0.5549 mL	1.3873 mL

Propylparaben

1 Cited Publications

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Propylparaben

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Publications Citing Use of MedChemExpress (MCE) Propylparaben

All Estrogen Receptor/ERR Isoforms

All Sodium Channel Isoforms

All PI3K Isoforms

All JNK Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Propylparaben Related Classifications

HY-N2026 Related Classifications