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Cat. No.: HY-15538R

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Ebrotidine (Standard)

Name: Ebrotidine (Standard)
Brand: MedChemExpress
SKU: HY-15538R
Price: 150.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: FI3542 (Standard))

Ebrotidine (Standard) (FI3542 (Standard)) is the analytical standard of Ebrotidine (HY-15538). This product is intended for research and analytical applications. Ebrotidine (FI3542) is a competitive histamine H₂ receptor (histamine H₂ receptor) antagonist with gastric acid secretion inhibitory and gastric mucosal protective effects. Ebrotidine alleviates gastric mucosal injury and epithelial cell apoptosis induced by Indomethacin (HY-14397) and Helicobacter pylori LPS (HY-D1056), and accelerates chronic gastric ulcer healing by promoting rapid recovery of IL-4 and inhibiting TNF-α, endothelin-1 (ET-1) and NOS-2. Ebrotidine can be used in studies on gastric ulcer healing, NSAID-induced gastric mucosal injury, Helicobacter pylori-associated gastritis, and H2 receptor-mediated gastric mucosal protection mechanisms.

For research use only. We do not sell to patients.

Purity : 98%
CAS No.: 100981-43-9
Formula: C₁₄H₁₇BrN₆O₂S₃
Molecular Weight:477.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ebrotidine (Standard) Chemical Structure

CAS No.: 100981-43-9

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The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 100981-43-9
Molecular Weight 477.42
Formula C₁₄H₁₇BrN₆O₂S₃
SMILES

O=S(C1=CC=C(Br)C=C1)(/N=C/NCCSCC2=CSC(NC(N)=N)=N2)=O
Synonyms

FI3542 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Romero A, et al. Study of the Population of Enterochromaffin-Like Cells in Mouse Gastric Mucosa after Long-Term Treatment with Ebrotidine. Toxicologic Pathology. 1996;24(2):160-165.

[2]. Romero A, et al. Effect of ebrotidine on the density of antral G-cells in the gastric mucosa in the rat. Cell proliferation. 1995 Jul;28(7):393-401.

[3]. Slomiany BL, et al. Involvement of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: Effect of ebrotidine. Inflammopharmacology. 2000;8(1):55-68.

[4]. Slomiany BL, et al. Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine. Scandinavian journal of gastroenterology. 1997 Jul;32(7):638-42.

[5]. Romero A, et al. Twenty-four-month oral carcinogenicity study of ebrotidine in rats. Teratogenesis, carcinogenesis, and mutagenesis. 1998;18(6):263-77.

[6]. Slomiany BL, et al. Effect of ebrotidine on Helicobacter pylori lipopolysaccharide-induced up-regulation of endothelin-1 in gastric mucosa. Journal of Endotoxin Research. 1999;5(5/6):279-285.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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