4 Results for "

complement factor Bb

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "complement factor Bb" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P72137
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment
Species:  
Source:  
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Cat. No.: HY-P992456

Target:  

Complement System

SAR-443809 is a monoclonal antibody targeting complement factor Bb that inhibits the alternative complement pathway. SAR-443809 blocks the cleavage of C3 and factor B via selective binding to the activated form factor Bb, with a KD of 7.3 nM for human factor Bb. SAR-443809 inhibits the amplification loop of the alternative complement pathway and C3 activation, reduces C3b deposition, and blocks the activation of pathways associated with intravascular and extravascular hemolysis. SAR-443809 can be used for research on hematological and renal disorders mediated by abnormal alternative complement pathway activity .
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Cat. No.: HY-P991022
CAS No.: 2842046-67-5
Synonyms: NM8074

Target:  

Complement System

Research Areas:  

Endocrinology

Ruxoprubart (NM8074) is an inhibitor of complement factor B (Bb subunit). Ruxoprubart selectively binds to active Bb to inhibit the alternative complement pathway without affecting the classical complement pathway. By blocking the activities of AP C3 and C5 convertases, Ruxoprubart effectively inhibits red blood cell hemolysis and reduces C3b deposition, thereby preventing intravascular and extravascular hemolysis. Ruxoprubart can be used in research related to paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, C3 glomerulopathy, and IgA nephropathy .
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Cat. No.: HY-P704903
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Cfb; Bf; H2-Bfcomplement factor B; EC 3.4.21.47; C3/C5 convertase; complement factor B Ba fragment; complement factor B Bb fragment
Species:  
Source:  
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