AX8819
AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC50 of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 928161-33-5
- Formule: C11H21N3O
- Masse moléculaire:211.30
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
DPP-2 0.88 nM (IC50) |
In Vitro
AX8819 potently and selectively inhibits purified DPP II with an IC50 of 0.88 nM, with no measurable activity against other tested DPP family enzymes[1].
AX8819 (0.88-44 μM) inhibits overexpressed DPP II activity in DPP II-293T HEK cells at all tested concentrations, inhibits endogenous DPP II activity in Jurkat cells at 4.4-44 μM[1].
AX8819 (0-44 μM; 16 h) exhibits very low non-specific cytotoxicity toward proliferating Jurkat cells at concentrations up to 44 μM[1].
AX8819 (4.4-44 μM; 4-16 h) induces apaptosis in resting PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:resting PBMCs
-
Concentration:4.4, 8.8, 22, 44 μM
-
Incubation Time:4, 8, 16 h
-
Result:Induces apaptosis in a time- and concentration-dependent manner.
Chemical Information
-
CAS No. 928161-33-5
-
Masse moléculaire 211.30
-
Formule C11H21N3O
-
SMILES
NCC[C@H](N)C(N1[C@@]2([H])[C@@](CCC2)([H])CC1)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AX8819 Related Classifications
HY-182374 Related Classifications
Powered by Bioz
Keywords