BuChE-IN-7
BuChE-IN-7 is a highly selective inhibitor of hBuChe and eqBuChE with IC50 values of 40 nM, 80 nM respectively. BuChE-IN-7 can promote cognitive with blood-brain penetration and improves situational and phobic memory, showing preference for new things.
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- CAS No.: 3041971-93-8
- Formule: C25H34N2O2
- Masse moléculaire:394.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
[1]|
hBCHE 40 nM (IC50) |
eqBCHE 80 nM (IC50) |
In Vitro
BuChE-IN-7 (compound (R)-29) (10 µM; 5 min) inhibits eqBuChE, hBuChE with IC50 values of 0.08 µM, 0.04 µM respectively[1].
BuChE-IN-7 (1, 10, 50 and 100 µM; 72 h) has hepatotoxicity in HepG2 cell line with an IC50 value of 2.85 µM. BuChE-IN-7 decreas the cell activity and shows weaker effect on CYP3A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
BuChE-IN-7 (10 mg/kg; i.p.; once daily for 6 days) has insignificant improvement the learning defect caused by scopolamine in mice[1].
BuChE-IN-7 (15 mg/kg and 30 mg/kg; i.p.; single dose) significantly promotes cognition and improves situational and phobic memory of mice, showing preference for new things[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3041971-93-8
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Masse moléculaire 394.55
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Formule C25H34N2O2
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SMILES
O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC[C@H](O)CNCC3CCCCC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BuChE-IN-7 Related Classifications
HY-152632 Related Classifications
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