CP 154526
CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities.
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- CAS No.: 157286-86-7
- Formule: C23H32N4
- Masse moléculaire:364.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.011 μM
Compound: 8, CP-154,526
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Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells
Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells
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[PMID: 21414781] |
CP 154526 displaces [125I][Tyr0]CRF from rat hippocampal CRF receptors (IC50 = 0.5 nM) and from pituitary CRF receptors (IC50 = 0.04 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[2]
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Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
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Administration:i.p.; once
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Result:Exhibited signs of anxiolytic-like activity.
Chemical Information
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CAS No. 157286-86-7
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Masse moléculaire 364.53
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Formule C23H32N4
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SMILES
CC1=C(N2C=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. J Lundkvist, et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol. 1996 Aug 8;309(2):195-200. [Content Brief]
[2]. D W Schulz, et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10477-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP 154526 Related Classifications
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