DM1-PEG4-DBCO
Based on 1 Customer Validation
DM1-(PEG)4-DBCO is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- Pureté: 96.11%
- Formule: C63H80ClN5O16
- Masse moléculaire:1198.79
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Help & FAQs
Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC
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Activité biologique
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Maytansinoids |
Chemical Information
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Appearance Solid
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Masse moléculaire 1198.79
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Formule C63H80ClN5O16
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Color Off-white to light yellow
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SMILES
COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(O[C@@]([C@@H](C)[C@@](O3)([H])[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 100 mg/mL (83.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (249 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8342 mL | 4.1709 mL | 8.3417 mL | 20.8544 mL |
| 5 mM | 0.1668 mL | 0.8342 mL | 1.6683 mL | 4.1709 mL | |
| 10 mM | 0.0834 mL | 0.4171 mL | 0.8342 mL | 2.0854 mL | |
| 15 mM | 0.0556 mL | 0.2781 mL | 0.5561 mL | 1.3903 mL | |
| 20 mM | 0.0417 mL | 0.2085 mL | 0.4171 mL | 1.0427 mL | |
| 25 mM | 0.0334 mL | 0.1668 mL | 0.3337 mL | 0.8342 mL | |
| 30 mM | 0.0278 mL | 0.1390 mL | 0.2781 mL | 0.6951 mL | |
| 40 mM | 0.0209 mL | 0.1043 mL | 0.2085 mL | 0.5214 mL | |
| 50 mM | 0.0167 mL | 0.0834 mL | 0.1668 mL | 0.4171 mL | |
| 60 mM | 0.0139 mL | 0.0695 mL | 0.1390 mL | 0.3476 mL | |
| 80 mM | 0.0104 mL | 0.0521 mL | 0.1043 mL | 0.2607 mL |
DM1-PEG4-DBCO Related Classifications
HY-136261 Related Classifications
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