Etelcalcetide
Based on 2 publication(s) in Google Scholar
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease.
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- CAS No.: 1262780-97-1
- Formule: C38H73N21O10S2
- Masse moléculaire:1048.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Etelcalcetide
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Activité biologique
Description
In Vitro
Etelcalcetide hydrochloride (0-100 µmol/L, 2 h) dose-dependently reduces parathyroid hormone (PTH) levels in human parathyroid cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL7/6J male mice
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Dosage:2.5 µg/h and 20 µg/h
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Administration:infusion, 3 days
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Result:Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 µg/h, but decreased the renal expression of Cyp24a1 with 20 µg/h[1]
Chemical Information
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CAS No. 1262780-97-1
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Masse moléculaire 1048.25
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Formule C38H73N21O10S2
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Synonyms
Velcalcetide; AMG 416; KAI-4169
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Sequence
Ac-dCys(disulfide bridge:Cys)-d(Ala-Arg-Arg-Arg-Ala-Arg)-NH2
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Sequence Shortening
Ac-dCys(disulfide bridge:Cys)-d(ARRRAR)-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Commun Biol
Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges. [Abstract]2024 Apr 25;7(1):501. PMID: 38664468 -
J Clin Endocrinol Metab
Heterogenous Origins of Calcium Homeostasis Disorders Arising from Five Heterozygous Calcium-Sensing Receptor Variants. [Abstract]2025 Jun 17;110(7):1865-1880. PMID: 39413244
Pureté et documentation
Références
[1]. [1]Van Megen WH, et al. Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1[J]. EBioMedicine. 2022 Apr;78:103947. [Content Brief]
[2]. Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39(3):396-403. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Etelcalcetide Related Classifications
HY-P1955 Related Classifications
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