DNAJB4 - DnaJ heat shock protein family (Hsp40) member B4 Gene

Also Known as DjB4; HLJ1; DNAJW

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11080

About DNAJB4

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,979,175-78,017,964 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 27.3), thyroid (RPKM 23.6) and 25 other tissues.

Summary

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

DNAJB4 Products (6)

mRNA Protein Name
NM_001317099.2 NP_001304028.1 dnaJ homolog subfamily B member 4 isoform a
NM_001317100.2 NP_001304029.1 dnaJ homolog subfamily B member 4 isoform b
NM_001317101.2 NP_001304030.1 dnaJ homolog subfamily B member 4 isoform c
NM_001317102.2 NP_001304031.1 dnaJ homolog subfamily B member 4 isoform c
NM_001317103.2 NP_001304032.1 dnaJ homolog subfamily B member 4 isoform d
NM_007034.5 NP_008965.2 dnaJ homolog subfamily B member 4 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ATPase activator activity IDA
IDA: Inferred from direct assay
24318877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21255413 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
21231916 GOA
Cellular Component GO Annotation Evidence Références Source
located in Z disc IDA
IDA: Inferred from direct assay
36264506 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB4 Protein Structure

DnaJ

DnaJ: DnaJ domain (4 - 65)

DnaJ_C

DnaJ_C: DnaJ C terminal domain (249 - 328)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily B member 4

  • DnaJ (Hsp40) homolog, subfamily B, member 4

DNAJB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
DNAJB4 Q9UDY4 RUVBL2 Homo sapiens Q9Y230
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03867 DNAJB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20546 Dnajb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27055 Dnajb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAJB4 VGNC VGNC:80183
Bos taurus DNAJB4 VGNC VGNC:55166
Rattus norvegicus DNAJB4 RGD RGD:1305826
Macaca mulatta DNAJB4 VGNC VGNC:106351
Mus musculus DNAJB4 MGD MGI:1914285
Canis familiaris DNAJB4 VGNC VGNC:49082
Others DNAJB4 NCBI