Cbx8 - chromobox 8 Gene

Also Known as Pc3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30951

Summary

Enables single-stranded RNA binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within histone ubiquitination and regulation of catalytic activity. Located in heterochromatin and nucleus. Part of PcG protein complex and ubiquitin Ligase complex. Is expressed in several structures, including brain. Orthologous to human CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Apr 2022]

Cbx8 Products (1)

mRNA Protein Name
NM_013926.1 NP_038954.1 chromobox protein homolog 8

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16359901 MGI
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
16537902 MGI
enables ubiquitin-protein transferase activator activity IDA
IDA: Inferred from direct assay
16359901 MGI
Cellular Component GO Annotation Evidence Références Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
16359901 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
16537902 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16537902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromobox protein homolog 8

  • chromobox homolog 8

  • mPc3

  • polycomb 3 homolog

Cbx8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Cbx8 Q9QXV1 Rnf2 Mus musculus Q9CQJ4
Pull Down
16359901
Intra
Cbx8 Q9QXV1 Ring1 Mus musculus O35730
Pull Down
16359901
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-141716 SW2_110A Inhibitor 99.19% Unkown
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS02015 CBX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19122 Cbx8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25612 Cbx8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbx8 NCBI NCBI:57332