IL12RB2 - interleukin 12 receptor subunit beta 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3595

About IL12RB2

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,307,364-67,398,724 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues and 23 paralogues. Broad expression in placenta (RPKM 2.3), brain (RPKM 0.9) and 18 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

IL12RB2 Products (6)

mRNA	Protein	Name
NM_001258214.1	NP_001245143.1	interleukin-12 receptor subunit beta-2 isoform b precursor
NM_001258215.1	NP_001245144.1	interleukin-12 receptor subunit beta-2 isoform c precursor
NM_001258216.1	NP_001245145.1	interleukin-12 receptor subunit beta-2 isoform d precursor
NM_001319233.1	NP_001306162.1	interleukin-12 receptor subunit beta-2 isoform b precursor
NM_001374259.2	NP_001361188.1	interleukin-12 receptor subunit beta-2 isoform a precursor
NM_001559.3	NP_001550.1	interleukin-12 receptor subunit beta-2 isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	8943050	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	8943050	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11114383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL12RB2 Protein Structure

Lep_receptor_Ig

IL6Ra-bind

fn3

0
200
400
600
800
862 a.a.

Protein Preferred Names	Protein Names
interleukin-12 receptor subunit beta-2	IL-12 receptor subunit beta-2

Related Diseases

Diseases	Alias
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Immunodeficiency 30	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency IMD30 Il12rb1 Deficiency Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency Msmd Due To Complete Il12rb1 Deficiency Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency Il-12râ1 Deficiency Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency Immunodeficiency, Type 30
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Rubella	German Measles Three Day Measles Rubella Nos
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Takayasu'S Arteritis Idiopathic Aortitis Young Female Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Inflammatory Bowel Disease 23	IBD23
Familial Behcet-Like Autoinflammatory Syndrome	Autoinflammatory Syndrome, Familial, Behcet-Like A20 Haploinsufficiency
Autoimmune Cholangitis	Autoimmune Cholangiopathy
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06684	IL12RB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22007	Il12rb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28525	Il12rb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990985	Efarindodekin alfa	Inhibitor	/	Unkown
HY-P992042	Anti-IL-12RB2 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL12RB2	MGD	MGI:1270861
Bos taurus	IL12RB2	VGNC	VGNC:30113
Macaca mulatta	IL12RB2	VGNC	VGNC:73708
Rattus norvegicus	IL12RB2	RGD	RGD:620026
Felis catus	IL12RB2	VGNC	VGNC:67757
Canis familiaris	IL12RB2	VGNC	VGNC:41935
Others	IL12RB2	NCBI