LPP - LIM domain containing preferred translocation partner in lipoma Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4026

About LPP

Cytogenetic location: 3q27.3-q28 Genomic coordinates (GRCh38): 3:188,153,021-188,890,671 (from NCBI)

This gene has 22 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 85 phenotypes. Ubiquitous expression in endometrium (RPKM 14.7), esophagus (RPKM 14.3) and 24 other tissues.

Summary

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

LPP Products (35)

mRNA	Protein	Name
NM_001167671.3	NP_001161143.1	lipoma-preferred partner isoform a
NM_001167672.3	NP_001161144.1	lipoma-preferred partner isoform b
NM_001375455.1	NP_001362384.1	lipoma-preferred partner isoform a
NM_001375456.1	NP_001362385.1	lipoma-preferred partner isoform a
NM_001375457.1	NP_001362386.1	lipoma-preferred partner isoform a
NM_001375458.1	NP_001362387.1	lipoma-preferred partner isoform a
NM_001375459.1	NP_001362388.1	lipoma-preferred partner isoform a
NM_001375460.1	NP_001362389.1	lipoma-preferred partner isoform a
NM_001375461.1	NP_001362390.1	lipoma-preferred partner isoform a
NM_001375462.1	NP_001362391.1	lipoma-preferred partner isoform a
NM_001375463.1	NP_001362392.1	lipoma-preferred partner isoform a
NM_001375464.1	NP_001362393.1	lipoma-preferred partner isoform a
NM_001375465.1	NP_001362394.1	lipoma-preferred partner isoform a
NM_001387663.1	NP_001374592.1	lipoma-preferred partner isoform a
NM_001387664.1	NP_001374593.1	lipoma-preferred partner isoform a
NM_001387665.1	NP_001374594.1	lipoma-preferred partner isoform a
NM_001387666.1	NP_001374595.1	lipoma-preferred partner isoform a
NM_001387667.1	NP_001374596.1	lipoma-preferred partner isoform a
NM_001387668.1	NP_001374597.1	lipoma-preferred partner isoform a
NM_001387669.1	NP_001374598.1	lipoma-preferred partner isoform a
NM_001387670.1	NP_001374599.1	lipoma-preferred partner isoform a
NM_001387671.1	NP_001374600.1	lipoma-preferred partner isoform a
NM_001387672.1	NP_001374601.1	lipoma-preferred partner isoform a
NM_001387673.1	NP_001374602.1	lipoma-preferred partner isoform a
NM_001387674.1	NP_001374603.1	lipoma-preferred partner isoform a
NM_001387675.1	NP_001374604.1	lipoma-preferred partner isoform c
NM_001387676.1	NP_001374605.1	lipoma-preferred partner isoform c
NM_001387677.1	NP_001374606.1	lipoma-preferred partner isoform d
NM_001387678.1	NP_001374607.1	lipoma-preferred partner isoform d
NM_001387679.1	NP_001374608.1	lipoma-preferred partner isoform d
NM_001387680.1	NP_001374609.1	lipoma-preferred partner isoform d
NM_001387681.1	NP_001374610.1	lipoma-preferred partner isoform d
NM_001387682.1	NP_001374611.1	lipoma-preferred partner isoform d
NM_001387683.1	NP_001374612.1	lipoma-preferred partner isoform d
NM_005578.5	NP_005569.1	lipoma-preferred partner isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15649318	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPP Protein Structure

LIM

0
100
200
300
400
500
612 a.a.

Protein Preferred Names	Protein Names
lipoma-preferred partner	LIM protein

LPP Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81285	LPP Antibody (YA993)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Monkey, Hamster
HY-P81285A	LPP Antibody (YA994)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84717	LPP Antibody (YA4414)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey, Hamster
HY-P84717A	LPP Antibody (YA4414)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey, Hamster
HY-P85263	LPP Antibody (YA4955)	WB; IHC-P; IHC-F; IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Monoblastic Leukemia	Acute Monocytic Leukemia Acute Myeloblastic Leukemia Type 5 Aml M5 Aml-M5 M5b Acute Differentiated Monocytic Leukemia Acute Monocytic/Monoblastic Leukemia
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Soft Tissue Chondroma	Extraskeletal Chondroma
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Prostate Carcinoma In Situ	Carcinoma In Situ Of Prostate Grade Iii Pin Pin Iii
Retinitis Pigmentosa 71	RP71 Retinitis Pigmentosa, Type 71
Infiltrating Lipoma	Intramuscular Lipoma
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Vacterl Association, X-Linked, With Or Without Hydrocephalus	VACTERLX X-Linked Vacterl Association Vacterl-H, X-Linked Vacterl Association, X-Linked Vacterl Association, X-Linked With Or Without Hydrocephalus Vacterl Association X-Linked With Or Without Hydrocephalus Vacterl Syndrome Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies X-Linked Vacterl-H Vacterl Association Vacterl Association With Hydrocephalus
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly	SRTD10 Short-Rib Thoracic Dysplasia 10 Without Polydactyly Short Rib-Polydactyly Syndrome
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-119013	VPC32183		/	Unkown
HY-RS07774	LPP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17623	Lpp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24083	Lpp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LPP	MGD	MGI:2441849
Rattus norvegicus	LPP	RGD	RGD:1310535