ARRB1 - arrestin beta 1 Gene

Also Known as ARB1; ARR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 408

About ARRB1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,260,122-75,351,661 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 3 paralogues. Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of Arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

ARRB1 Products (2)

mRNA	Protein	Name
NM_004041.5	NP_004032.2	beta-arrestin-1 isoform A
NM_020251.4	NP_064647.1	beta-arrestin-1 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	15611106	GOA
enables angiotensin receptor binding	IPI IPI: Inferred from physical interaction	15611106	GOA
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	23886940	GOA
NOT enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	16325578	GOA
enables insulin-like growth factor receptor binding	IPI IPI: Inferred from physical interaction	15878855	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	16325578	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15878855	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	10521508	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16378096	GOA
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23886940	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16378096	GOA
involved in negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	16378096	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16378096	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10644702	GOA
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	15611106	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23633677	GOA
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	22457824	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16325578	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15878855	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	15878855	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16325578	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	15611106	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23886940	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IDA IDA: Inferred from direct assay	16325578	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10823817	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15611106	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16325578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRB1 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
beta-arrestin-1	arrestin 2

ARRB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ARRB1	P49407	PPM1B	Homo sapiens	O75688	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	ZRANB2	Homo sapiens	O95218	Anti Bait CoIP	17353931
Intra	ARRB1	P49407	ZRANB2	Homo sapiens	O95218	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	S100A9	Homo sapiens	P06702	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Y2H Prey Pooling	32296183
Intra	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Y2H Array	32296183
Intra	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Validated Y2H	32296183
Intra	ARRB1	P49407	CD247	Homo sapiens	P20963	Anti Tag CoIP	24502978
Intra	ARRB1	P49407	CD247	Homo sapiens	P20963	IF	24502978
Intra	ARRB1	P49407	CD247	Homo sapiens	P20963	Pull Down	24502978
Intra	ARRB1	P49407	NCL	Homo sapiens	P19338	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	GSN	Homo sapiens	P06396	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	PKM	Homo sapiens	P14618	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	TP53	Homo sapiens	P04637	Anti Bait CoIP	21857681
Intra	ARRB1	P49407	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	21857681
Intra	ARRB1	P49407	GNAQ	Homo sapiens	P50148	Anti Tag CoIP	23353685
Intra	ARRB1	P49407	PRP4K	Homo sapiens	Q13523	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	TCOF1	Homo sapiens	Q13428	Anti Bait CoIP	17353931
Intra	ARRB1	P49407	TCOF1	Homo sapiens	Q13428	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	33961781
Intra	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Bait CoIP	17353931
Intra	ARRB1	P49407	GNAS	Homo sapiens	Q5JWF2	Anti Bait CoIP	23353685
Intra	ARRB1	P49407	GNAS	Homo sapiens	Q5JWF2	Anti Tag CoIP	23353685
Intra	ARRB1	P49407	STK38	Homo sapiens	Q15208	Anti Tag CoIP	17620599
Intra	ARRB1	P49407	MAP3K5	Homo sapiens	Q99683	Peptide Array	19782076
Intra	ARRB1	P49407	SRC	Homo sapiens	P12931	Anti Bait CoIP	19202075
Intra	ARRB1	P49407	SRC	Homo sapiens	P12931	Anti Bait CoIP	16432186
Intra	ARRB1	P49407	EDNRA	Homo sapiens	P25101	Anti Bait CoIP	19202075
Intra	ARRB1	P49407	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	19202075
Intra	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	21988832
Intra	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H	21988832
Intra	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	31515488
Intra	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	25416956
Intra	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Pooling	16189514
Intra	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Array	31515488
Intra	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
Intra	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Validated Y2H	32296183
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Confocal	21988832
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Array	32296183
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Pooling	16189514
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Array	31515488
Intra	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Prey Pooling	32296183
Intra	ARRB1	P49407	YY1	Homo sapiens	P25490	Y2H	19879840
Intra	ARRB1	P49407	YY1	Homo sapiens	P25490	Anti Bait CoIP	19879840
Intra	ARRB1	P49407	YY1	Homo sapiens	P25490	Anti Tag CoIP	19879840
Intra	ARRB1	P49407	PPM1A	Homo sapiens	P35813	Anti Tag CoIP	17620599

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARRB1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7606	ARRB1/Beta-Arrestin 1 Protein, Human (His)	P49407 (M1-R418)	≥ 95%, as determined by reducing SDS-PAGE.

ARRB1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80569	beta Arrestin 1 Antibody (YA822)	WB	Human
HY-P80569A	beta Arrestin 1 Antibody (YA822)(PBS only)	WB	Human
HY-P810789	Phospho-Beta-arrestin-1 (Ser412) Antibody (YA10032)	WB	Human
HY-P85544	beta Arrestin 1 Antibody (YA5236)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Placenta Praevia	Placenta Previa Haemorrhage From Placenta Previa Placenta Previa Haemorrhage Lateral Placenta Low Implantation Of Placenta Nos Or With Haemorrhage Total Placenta Previa Total Placenta Praevia Nos Or With Haemorrhage Placental Previa Haemorrhage Pp - [Placenta Previa] Placenta Previa Marginalis Placenta Previa Partialis Partial Placenta Previa Placenta Previa Centralis Low Implantation Of Placenta Low Implantation Or Insertion Of Placenta Low Insertion Of Placenta Low Lying Placenta Marginal Placenta Marginal Placenta Praevia Nos Or With Haemorrhage Marginal Placenta Previa Marginal Placental Haemorrhage Partial Placenta Praevia Nos Or With Haemorrhage
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Precocious Puberty, Central, 1	CPPB1 Central Precocious Puberty 1 Precocious Puberty, Central 1 Puberty, Precocious, Central, Type 1
Whim Syndrome 1	Whim Syndrome Whims Warts, Hypogammaglobulinemia, Infections, And Myelokathexis WHIMS1 Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1 Myelokathexis, Isolated Wilm Warts-Infections-Leukopenia-Myelokatexis Syndrome Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Placental Abruption	Abruptio Placentae Abruptio Placenta Abortion, Threatened Threatened Miscarriage Haemorrhage Specified As Due To Threatened Abortion Spontaneous Threatened Abortion
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Malignant Secondary Hypertension

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01028	ARRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18162	Arrb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24636	Arrb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARRB1	MGD	MGI:99473
Bos taurus	ARRB1	VGNC	VGNC:26169
Macaca mulatta	ARRB1	VGNC	VGNC:70021
Felis catus	ARRB1	VGNC	VGNC:68263
Rattus norvegicus	ARRB1	RGD	RGD:2156
Canis familiaris	ARRB1	VGNC	VGNC:38136
Others	ARRB1	NCBI