PRPF4B - pre-mRNA processing factor 4B Gene

Also Known as PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8899

About PRPF4B

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:4,021,300-4,064,983 (from NCBI)

This gene has 9 transcripts (splice variants), 240 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (CLK) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

PRPF4B Products (1)

mRNA Protein Name
NM_003913.5 NP_003904.3 serine/threonine-protein kinase PRP4 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15452250 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10799319 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of hippo signaling IDA
IDA: Inferred from direct assay
29695716 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
29695716 GOA
involved in regulation of mitotic cell cycle spindle assembly checkpoint IDA
IDA: Inferred from direct assay
17998396 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
12077342 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: Inferred from direct assay
20118938 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
17998396 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
12077342 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
29695716 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20118938 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF4B Protein Structure

Pkinase

Pkinase: Protein kinase domain (691 - 1003)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1007 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PRP4 homolog

  • PRP4 kinase

PRPF4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Imaging
17513757
Intra
PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Anti Bait CoIP
17513757
Intra
PRP4K Q13523 KLF13 Homo sapiens Q9Y2Y9
Y2H
17513757
Cross
PRP4K Q13523 gag Human immunodeficiency virus P04590
Protein Kinase Assay
15452250
Cross
PRP4K Q13523 gag Human immunodeficiency virus P04590
Anti Tag CoIP
15452250
Cross
PRP4K Q13523 gag Human immunodeficiency virus P04590
Pull Down
15452250
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11214 PRPF4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRPF4B VGNC VGNC:64377
Canis familiaris PRPF4B VGNC VGNC:45028
Rattus norvegicus PRPF4B RGD RGD:1307784
Bos taurus PRPF4B VGNC VGNC:33381
Macaca mulatta PRPF4B VGNC VGNC:76276
Mus musculus PRPF4B MGD MGI:109584
Others PRPF4B NCBI